NJMS National TB Center

Introduction

References


Transmission and Pathogenesis

Transmission

Pathogenesis

Classification System


Epidemiology of TB in the United States

Trends

Risk Groups

Outbreaks and Transmission Sites


Screening for TB Disease and Infection

Groups That Should Be Screened

Tuberculin Skin Testing

Administration of the Tuberculin Test

Classification of the Tuberculin Reaction

Anergy Testing

Two-Step Testing


Diagnosis of TB

Medical History

Physical Examination

Tuberculin Skin Testing

Radiographic Examination

Diagnostic Microbiology

Specimen Collection

Laboratory Examination


Preventive Therapy: Treatment of TB Infection

Candidates

Standard Regimens

Alternative Regimens

Monitoring


Treatment of TB Disease

Adherence

Pulmonary TB

Extrapulmonary TB

Pregnant or Lactating Women

Children and Adolescents

Drug-Resistant TB

Persons with Additional Medical Problems

Monitoring

Adverse Reactions

Response to Treatment


Infection Control

Infectiousness

Infection Control

Administrative Controls

Engineering Controls

Personal Respirators


Community TB Control

Role of the Health Department

Surveillance

Containment

Contact Investigation

Overall Planning and Policy

Role of Voluntary Organizations


BCG Vaccination

Recommendations for the Use of BCG Vaccine

Interpretation of Tuberculin Reactions in Persons with a History of BCG Vaccination


Tables

Regimen Options for Treatment

First-Line TB Drugs

TB Drugs in Special Situations

Second-Line TB Drugs


Selected Bibliography

Self-Test