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Special Index

Table of Contents

UMDNJ MATTERS

NJMS
New Jersey Medical School

Publications:

"Activity-Related Quality of Life in Rehabilitation and Traumatic Brain Injury," by Mark Johnston, PhD, professor, and Carol Miklos, PhD, instructor, Physical Medicine and Rehabilitation, was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, Suppl. 2, December 2002.

"Anti-U1A Monoclonal Antibodies Recognize Unique Epitope Targets of U1A Which Are Involved in the Binding of U1 RNA" by Carol Lutz, PhD, assistant professor, Department of Biochemistry and Molecular Biology, et al., was in the Journal of Molecular Recognition, Vol. 15, May–June 2002.

"Assessing Physicians' Interpersonal Skills," by Scott Millis, PhD, associate professor, Sheela Jain, MD, professor, Mary Eyles, PhD, RN, clinical assistant professor, David Tulsky, PhD, clinical assistant professor, Scott Nadler, DO, associate professor, Patrick Foye, MD, assistant professor, Elie Elovic, MD, assistant professor, and Joel DeLisa, MD, MS, professor and chair, Physical Medicine and Rehabilitation, was in the American Journal of Physical Medicine and Rehabilitation, Vol. 81, No. 12.

"Central Post-Stroke Pain Syndrome-Yet Another Use for Gabapetin?" by Boging Chen, MD, PhD, assistant professor, Todd Stitik, MD, associate professor, Patrick Foye, MD, assistant professor, Scott Nadler, DO, associate professor, and Joel DeLisa, MD, MS, professor and chair, Physical Medicine and Rehabilitation, was in the American Journal of Physical Medicine and Rehabilitation, Vol. 81, No. 9.

"Clerkship Timing and Disparity in Performance of Racial-ethnic Minorities in the Medicine Clerkship," by Jo-Ann Reteguiz, MD, associate professor, Medicine, Amy Davidow, PhD, assistant professor, Preventive Medicine and Community Health, Marilyn Miller, MD, associate professor, Medicine, and W. G. Johanson, Jr., MD, professor, Medicine, was in the Journal of the National Medical Association, Vol. 94, 2002.

"Clerkship Order and Performance on Family Medicine and Internal Medicine National Board of Medical Examiners Exams," by Jo-Ann Reteguiz, MD, associate professor, Medicine, and Jesse Crosson, PhD, assistant professor, Family Medicine, was in Family Medicine, Vol. 34, 2002.

"Dissociating Basal Forebrain and Medial Temporal Amnesic Insights from Classical Conditioning," by Deborah Bryant, PhD, instructor, and John DeLuca, PhD, professor, Physical Medicine and Rehabilitation, et al., was in Integrative Physiological and Behavioral Science, Vol. 37, No. 2, April–June 2002.

"Functional Deficits in Athletes With a History of Low Back Pain: A Pilot Study," by Scott Nadler, DO, associate professor, Peter Moley, MD, resident, Gerard Malanga, MD, associate professor, Mariam Rubbani, MD, resident, and Joseph Feinberg, MD, assistant professor, Physical Medicine and Rehabilitation, et al., was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, December 2002.

RESEARCH GRANT

UH/NJMS AWARDED GRANT FOR PALLIATIVE SERVICES

UMDNJ's University Hospital(UH)/New Jersey Medical School (NJMS) is one of four healthcare institutions nationwide to receive a grant from the Robert Wood Johnson Foundation program, Promoting Excellence in End-of-Life Care. The three-year, $375,000 grant will be used to develop an exportable model of palliative care in the trauma/surgical intensive care unit in an inner city setting. Principal investigators are Patricia Murphy, RN, PhD (left), advanced practice nurse for ethics and bereavement, and Anne Mosenthal, MD (right), director of surgical intensive care at UH and associate professor of surgery at NJMS.

A core team, already in place, will introduce palliative care tools and practices into the hospital's existing clinical structures and train selected nurses and physician assistants as 24-hour palliative care experts.

"Traditional palliative care programs are focused on patients with lengthy, terminal illnesses such as cancer or AIDS," reports Mosenthal. "Our model is based on acute and critical care. Our patients are often young and healthy, and then suddenly, because of a traumatic injury, are critically ill. These types of cases mean that our clinical, spiritual and emotional experts must work together during a crisis situation."

Murphy notes that palliative care should be available to everybody who can benefit from it, not just those who come through the E.R. or who are going to die. "Our patients come from trauma, liver transplant and general surgery. Activities are centered in the SICU, then extended into the ER and step-down units. We want to give everyone the best care possible."

Promoting Excellence in End-of-Life Care, a national program, selected grantees from a highly competitive pool of 242 applicants.

"Functional Magnetic Resonance Imaging Technology and Traumatic Brain Injury Rehabilitation: Guidelines for Methodological and Conceptual Pitfalls," by Frank Hillary, PhD, instructor, and John DeLuca, PhD, professor, Physical Medicine and Rehabilitation, et al., was in the Journal of Head Trauma Rehabilitation, Vol. 17, No. 5, 2002.

"Managing Conflict in the Urban Health Care Setting: What Do ‘Experts’ Know?" coauthored by Cheryl Kennedy, MD, associate professor, Psychiatry, and Preventive Medicine and Community Health, was in the Journal of Health Care Law and Policy, Vol. 5, No. 2: University of Maryland School of Law.

"Modified Constraint-Induced Therapy in Chronic Stroke," by Stephen Page, PhD, assistant professor, and Sue Ann Sisto, PhD, assistant professor, Physical Medicine and Rehabilitation, et al., was in the American Journal of Physical Medicine and Rehabilitation, Vol. 81, 2002.

"Quality of Life Measurement in Rehabilitation Medicine: Building an Agenda for the Future," by David Tulsky, PhD, associate professor, and Mitchell Rosenthal, PhD, professor, Physical Medicine and Rehabilitation, was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, Suppl. 2, December 2002.

"Scaling of the Revised Oswestry Low Back Pain Questionnaire," by Marla Shawaryn, PhD, instructor, Physical Medicine and Rehabilitation, et al., was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, November 2002.

"Silent Autonomic Dysreflexia During a Routine Bowel Program in Persons With Traumatic Spinal Cord Injury: A Preliminary Study," by Steven Kirshblum, MD, associate professor, Physical Medicine and Rehabilitation, et al., was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, December 2002.

"Predictors of Driving Outcome After Traumatic Brain Injury," by Joseph Ricker, PhD, associate professor, and Scott Millis, PhD, associate professor, Physical Medicine and Rehabilitation, et al., was in the Archives of Physical Medicine and Rehabilitation, Vol. 83, October 2002.

"Intramuscular Injection of Botulinum Toxin for the Treatment of Wrist and Finger Spasticity After a Stroke," by Elie Elovic, MD, assistant professor, Physical Medicine and Rehabilitation, et al., was in the New England Journal of Medicine, Vol. 347, No. 6, August 2002.

"Telerehabilitation Needs: A Survey of Persons with Acquired Brain Injury," by Joseph Ricker, PhD, associate professor and Mitchell Rosenthal, PhD, professor, Physical Medicine and Rehabilitation, et al., was in the Journal of Head Trauma Rehabilitation, Vol. 17, No. 3, 2002.

"Timing of Prophylactic Surgery in Prevention of Diverticulitis Recurrence: A Cost-Effectiveness Analysis," by Robert Richards, MD, associate professor, Division of Gastroenterology, was in Digestive Diseases and Sciences, Vol. 47, September 2002.

 

BOOK REVIEW

STRENGTH FOR THEIR JOURNEY: FIVE ESSENTIAL DISCIPLINES AFRICAN-AMERICAN PARENTS MUST TEACH THEIR CHILDREN AND TEENS

by Robert L. Johnson, MD, FAAP,
and Paulette Stanford, MD
Broadway Books

Strength for Their Journey is the result of more than 20 years of collaborative work by Robert Johnson, MD, and Paulette Stanford, MD. This hands-on guide focuses on the art of successful parenting and the many social challenges African-American children and their parents face each day. It offers insights into five interconnected disciplines the authors think are essential to growing up African-American in the U.S. today:

• traditional discipline—the strength to embrace parental boundaries;

• racial discipline—the strength to negotiate the realities of being a racial minority;

• emotional discipline—the strength to resist negative peer pressure and temptation;

• practical discipline—the strength to excel in school, career, and financial pursuits;

• mind-body discipline—the strength to maintain positive physical, mental, and spiritual health.

The book also seeks to inspire African-American youths to feel good about themselves and their heritage, to help them deal with prejudice and racial profiling, and fortify themselves against the dangers of violence, substance abuse and unsafe sex. Parents are also advised how to help children develop financial responsibility and career skills.

About the authors: Johnson is professor and interim chair in the Department of Pediatrics, and professor of psychiatry at UMDNJ-New Jersey Medical School (NJMS). He has been featured on numerous news shows, from ABC television's "20/20" to the Fox channel's "O'Reilly Factor," and serves as a medical and cultural advisor on NBC's "ER." He is also a member of the planning board for the U.S. Surgeon General's Report on Youth Violence. Stanford is an assistant professor of clinical pediatrics, and medical director of START, an adolescent-HIV program at NJMS. She is also the principal investigator for a NIH-research study on high-risk adolescent behavior.

"Traumatic Tetraplegia: Noninvasive Respiratory Management in the Acute Setting," by John Bach, MD, professor, Physical Medicine and Rehabilitation, was in the American Journal of Physical Medicine and Rehabilitation, Vol. 81, No. 10.

Adnan I. Qureshi, MD, Director, Cerebrovascular Program, Neurology and Neurosciences, received the 2003 American Medical Association Foundation Leadership Award, which is part of the American Medical Association Foundation's Excellence in Medicine Award Series. He was one of 24 physicians from all over the country and the only neurologist to receive this award, which was given for his work in improving the understanding of stroke among elected officials and the public.

Grants:

Mohamed Abdel-Rahman, PhD, professor, Pharmacology and Physiology, received a two-year, $70,000 grant from the Environmental Protection Agency for the Sixth Annual Workshop on "The Use of Data in Developing Specific Adjustment Factors."

Amutha Boominathan, PhD, postdoctoral fellow, Pharmacology and Physiology, received a two-year, $77,600 grant from the American Heart Asso-ciation for the study of "Molecular Characterization of Tom40p."

Michael Brimacombe, PhD, associate professor, Preventive Medicine, with co-principal investigators, Susan Adubato, PhD, assistant professor, Pediatrics, Barbie Zimmerman-Bier, MD, assistant professor, Pediatrics, and Bill Halperin, MD, PhD, professor, Preventive Medicine, received a one-year, $197,597 grant from the Centers for Disease Control and Prevention and the Association of Schools of Public Health to study "A Fetal Alcohol Education and Training Program for New Jersey."

Walter Durán, PhD, professor, Pharmacology and Physiology, received a five-year, $1,935,508 grant from the National Institutes of Health to study "Control of Microcirculatory Exchange Function."

James Patrick O'Connor, PhD, assistant professor, Orthopedics, received a one-year, $50,000 grant from the Arthritis Foundation, New Jersey Chapter, to "Investigate the COX2 Function in Bone Metabolism."

 

BOOK REVIEW

HEART TO HEART:
THE TWENTIETH CENTURY BATTLE AGAINST CARDIAC DISEASE–AN ORAL HISTORY

Allen Weisse, MD
Rutgers University Press

The twentieth century was a remarkable time of medical research productivity and progress in the treatment of heart disease. Methods of diagnosis, treatment, and prevention that were unknown or scarcely imagined at the start of the century have now been incorporated into daily medical practice. In Heart to Heart, a collection of interviews with the physicians who made groundbreaking and lifesaving discoveries in heart research and treatment in the twentieth century, 16 pioneering physicians talk about their challenges and triumphs in conquering a disease that affects millions worldwide. The interviews bring readers a unique opportunity to meet an extraordinary group of cardiologists as they candidly discuss their pioneering work.

Allen B. Weisse, MD, presents in-depth conversations with some of the world's most renowned cardiologists and surgeons. His interviews bring a special vitality to the doctors' recollections of the people and events that influenced them, their motivations, their problems, their interactions with their contemporaries, and their hopes and beliefs for the future. Since not every doctor who has made important contributions to the treatment and prevention of heart disease could be interviewed for this volume, Weisse includes a biographical section listing other prominent cardiologists and surgeons as well as a list of recommended reading. This comprehensive history will be a resource for any student of cardiology or general medicine.

About the author: Weisse is a clinical professor of medicine at UMDNJ-New Jersey Medical School, where he has worked for more than three decades. He is past president of the Medical History Society of New Jersey and a member of the American Association for the History of Medicine and the American Osler Society. He is also the author of Medicine: State of the Art, the award-winning Conversations in Medicine, The Staff and the Serpent: Pertinent and Impertinent Observations on the World of Medicine, and Medical Odysseys.

Paul Palumbo, MD, professor, Pediatrics, received a one-year, $202,200 grant from the Pediatric AIDS Foundation for "Mapping Viral Epitopes for Evidence of Immune Escape."

Vanessa Routh, PhD, assistant professor, Pharmacology and Physiology, received a four-year, $1,402,300 grant from the National Institutes of Health to study "Glucosensing Neurons in Euglycemia Hypoglycemia in HAAF."Natalia Shirokova, PhD, assistant professor, Pharmacology and Physiology, received a three-year, $245,641 grant from the Muscular Dystrophy Association to study "Metabolic Control of Calcium Signaling in Skeletal Muscle."

Professional Activities:

Gerard Malanga, MD, associate professor, Physical Medicine and Rehabilitation, presented "Open-label Trial Evaluating Tizandine for Myofascial Pain Syndrome," at the International Association for the Study of Pain annual meeting held in San Diego, Ca.

Honors:

Vincent Barba, MD, assistant professor, Medicine, has been elected Fellow of the American College of Physicians and American Society of Internists.

Joel DeLisa, MD, MS, professor and chair, Physical Medicine and Rehabilitation, was elected to the Administrative Board of the Council of Academic Societies of the Association of American Medical Colleges for a two-year term.

Walter Durán, PhD, professor, Pharmacology and Physiology, was elected a member of the Pharmacology Study Section, Center for Scientific Review of the National Institutes of Health. He will serve for four years.

Mark Johnston, PhD, professor, Physical Medicine and Rehabilitation, received the Distinguished Member Award for his significant contribution to the development and functioning of the American Congress of Rehabilitation Medicine (ACRM), demonstrated evidence of leadership skills, organizational abilities, and public service. The award was given by the American Congress of Rehabilitation Medicine at their annual conference held in Philadelphia.

Gerard Malanga, MD, associate professor, Physical Medicine and Rehabilitation, was recently named to the senior editorial board of SpineUniverse.com, an information/ education Web site for patients and physicians regarding spine problems. He will be assisting in the development and oversight of the non-operative aspects of spine care on this site.

Sue Ming, MD, PhD, assistant professor, Neurosciences, has been selected as Healthcare Professional of the Year by the Center for Outreach and Services to the Autism Community, a comprehensive "information source" for families of autistic children.

SPH
School of Public Health

Publications:

"Cohort Case-control Design and Analysis for Clustered Failure Time Data," co-authored by Shou-En Lu, PhD, assistant professor, Biometrics, was in Biometrics, Vol. 58, 2002.

"Length of Hospital Stay, Obstetric Conditions at Childbirth and Maternal Readmission: A Population-based Cohort Study," co-authored by Kitaw Demissie, MD, PhD, assistant professor, Epidemiology, was in the American Journal of Obstetrics and Gynecology, Vol. 187, 2002.

"The Effect of Interior Lead Hazard Controls on Children's Blood Lead Concentrations: A Systematic Evaluation," co-authored by George Rhoads, MD, PhD, associate dean, Academic Affairs, Piscataway/New Brunswick, and professor and acting director, Epidemiology Division, was in Environmental Health Perspectives, 2002.

Professional Activities:

Diane Brown, PhD, professor, Health Education and Behavioral Science, and executive director, Institute for the Elimination of Health Disparities, presented "Recruitment and Retention of Women in Clinical Studies and the Critical Role of Relevance" at the Office of Research on Women's Health in Washington.

M. Jane Lewis, DrPH, assistant professor, School of Public Health, presented "Risk Communication 101—What You Should Know" at the Society for Public Health Education’s 53rd annual meeting in Philadelphia.

Honors:

Diane Abatemarco, PhD, MSW, assistant professor, received the Public Health Social Work Outstanding Achievement Award for 2002 at the American Public Health Association annual meeting in Philadelphia.

UBHS
University Behavioral Healthcare

RESEARCH GRANT

INSTITUTE ANNOUNCES GRANTS TO STUDY NEGLECTED CHILDREN

The Institute for the Study of Child Development at UMDNJ-Robert Wood Johnson Medical School has received two grants underwritten by the National Institutes of Health.

The first, "Emotions and Behavioral Outcomes in Neglected Children," is a five-year grant for $1,879,745, funded by the National Institute of Mental Health (NIMH) and the National Institute on Drug Abuse (NIDA). The study uses a conceptual model to examine how neglect affects children's cognitive behavior and emotions, which can lead to subsequent behavioral problems. Michael Lewis, PhD, University Distinguished Professor of Pediatrics and Psychiatry, is the principal investigator. Margaret W. Sullivan, PhD, professor of pediatrics, is the co-investigator.

The second, "Developmental Effects of Prenatal Cocaine Exposure," is a five-year, $5,011,393 continuation grant, funded by the NIDA. The developmental teratology study, in its eleventh year, examines the cognitive and emotional development of infants who were exposed to cocaine in utero. Investigators will also search to see if the specificity of cocaine effects, found at younger ages, continues to be present in pre- to early adolescents. Other areas of analysis will include peer relationships, psychological adjustment, and initiation of high-risk behaviors like substance use, delinquency, and unsafe sex. Lewis is the principal investigator. Margaret Bendersky, PhD, professor of pediatrics, is the co-investigator.

Grants:

The COPSA Institute of Alzheimer's Disease and Related Disorders received a three-year, $1,916,415 grant from the New Jersey Department of Health and Senior Services. Peter Aupperle, MD, associate professor, and Andrew Coyne, PhD, associate professor, Psychiatry, serve as the grant coordinators.

The Violence Institute of New Jersey received a five-year, $950,000 grant from the Centers for Disease Control and Prevention/New Jersey Department of Health and Senior Services to develop a New Jersey Violent Death Reporting System. This system will bring together data on homicides and suicides from a variety of different sources to form a more complete picture of the incidents. Bruce Stout, PhD, executive director, is the principal investigator.

NJDS
New Jersey Dental School

Publications:

"Actinomycosis," by Talib Najjar, DMD, PhD, professor, Oral and Maxillofacial Surgery, primary author, was in eMedicine Journal, www.eMedicine.com, Inc., May 2002, Vol. 3, No. 3.

"Biofilm Dispersal of Neisseria Subflava and Other Phylogenetically Diverse Oral Bacteria," co-authored by Jeffrey Kaplan, PhD, assistant professor, Oral Biology, and Daniel Fine, DDS, professor and acting chair, Oral Biology, was in Applied and Environmental Microbiology, Vol. 68, No. 10, October 2002.

"Developing a Consensus for Restorative Procedures in Pediatric Dentistry," by Milton Houpt, DDS, PhD, professor and chair, Pediatric Dentistry, was in the September/ October issue of Pediatric Dentistry, Vol. 24, No. 5.

"Easy Placement of Open Coil Springs," by Robert Binder, DMD, professor and interim chair, Orthodontics, was in the Journal of Clinical Orthodontics, Vol. 36, No. 11, November 2002.

"Jaw: Cysts, Tumors, and Nontumorous Lesions," co-authored by Shahid Aziz, DMD, MD, assistant professor, Oral and Maxillofacial Surgery, was in Volume 1 of Head and Neck Imaging, 4th edition. He also co-authored "Management of the Pregnant Oral and Maxillofacial Surgery Patient" in the Journal of Oral and Maxillofacial Surgery, Vol. 60, December 2002.

"Prostate Carcinoma Metastasis to the Mandible: Report of a Case," by Robert Laski, DMD, postdoctoral student, Vincent Ziccardi, DDS, MD, associate professor and chair, and Talib Najjar, DMD, PhD, professor, Oral and Maxillofacial Surgery, was in the Journal of the New Jersey Dental Association, Vol. 75, No. 3, 2002.

Professional Activities:

Michael Arvystas, DMD, clinical professor, Orthodontics, presented "Interdisciplinary Esthetic Dentistry: Dental Facial Therapy," to participants at the annual meeting of the American Dental Association held in New Orleans.

Maano Milles, DDS, professor, Oral and Maxillofacial Surgery, obtained a patent from the U.S. Patent and Trademark Office for a nitrous oxide scavenger collar device, whose purpose is to evacuate nitrous oxide from the operatory area.

Evan Spivack, DDS, clinical associate professor, Pediatric Dentistry, presented "The Aging Patient: What You Need to Know" at the annual session of the Academy of General Dentistry held in Honolulu.

Vincent Ziccardi, DDS, MD, associate professor and chair, Oral and Maxillofacial Surgery, presented "Trigeminal Nerve Injuries" to dentists at a meeting of the Raritan Valley Study Club held at JFK Hospital in Edison.

RESEARCH GRANT

NJDS RESEARCHERS LEAD INTERNATIONAL STUDY

Some 600 children between the ages of 9 and 15 from eight countries are part of an international study, led by Hillary Broder, PhD, MEd, professor and acting chair of the Department of Community Health at NJDS. The grant is aimed to develop a culturally-sensitive measure of children’s oral health-related quality of life. The team’s principal investigator was awarded two grants from the National Institute of Dental Research for a total of approximately one million dollars to develop and test the questionnaire’s sensitivity, validity and reliability.

"We are collecting data from children and their caregivers to better understand how oral health conditions such as crooked teeth, cavities, bad breath and facial appearance impact on a child’s self-esteem, health perceptions, social behaviors and psychological well-being. For example, are they teased or bullied? Do they avoid meeting new people or have high rates of absenteeism from school?" Instrument development is a multi-staged process that includes various steps to ensure that the instrument is psychometrically-sound. The questionnaire is called the Child Oral Health Impact Profile and it is now available in English, Spanish, Chinese, Dutch, French, and Portuguese. It is designed to assess oral health-related quality of life for epidemiological study (e.g., to measure health disparities) as well as for an outcome measure (e.g., to assess the effect of treatment on quality of life).

In addition to NJDS, New York University and the University of Connecticut are participating from the U.S. Sites outside the U.S. include: McGill University and the University of Toronto, as well as universities in New Zealand, the Netherlands, France, Brazil, England, Hong Kong and South Africa.

Honors:

Kerry McKay, DMD, MD, associate professor, Oral and Maxillofacial Surgery, was made a Fellow of the International College of Dentists at the annual session of the American Dental Association held in New Orleans.

Mario Ramos, DMD, clinical associate professor, Pediatric Dentistry, was elected treasurer of the National Hispanic Dental Association.

SOM
School of Osteopathic Medicine

Publications:

"Breastfeeding Initiation Rates Derived from Electronic Birth Certificate Data in New Jersey" co-authored by Lori Feldman-Winter, MD, associate professor, Pediatrics, was in the Journal of Human Lactation, 2002.

"Valproic Acid-Associated Pancreatitis: Case Series and Literature Review," co-authored by Lori Feldman-Winter, MD, associate professor, and Gary McAbee, DO, chair, Pediatrics, was in Pediatric Neurology, December 2002.

Professional Activities:

Carman Ciervo, DO, associate professor and chair, Family Medicine, presented "Family Medicine Residency Training in Headache Management and Its Long Term Effects on Diagnosis and Treatment of Headaches" at the National Headache Foundation Conference in Palm Springs.

Esther Deblinger, PhD, clinical director, Center for Children's Support, conducted a pre-conference seminar entitled "Treating Children and Adolescents Who Have Suffered Abuse" at the 21st Annual Research and Treatment Conference of the Association for the Treatment of Sexual Abusers in Montreal.

Lori Feldman-Winter, MD, associate professor, Pediatrics, participated in the executive committee meeting of the Section on Breastfeeding at the American Academy of Pediatrics National Conference and Exhibition in Boston. She also conducted a workshop on "Integrating Breastfeeding Education to Eliminate Disparities" at Hospital Episcopal San Lucas, Ponce, Puerto Rico and at University Pediatric Hospital in San Juan.

Frank Filipetto, DO, residency program director, Family Medicine, presented "A Review of the Literature on Culturally Competent Patient Education" at the Society of Teachers of Family Medicine’s 24th Annual Conference on Patient Education in Ft. Lauderdale.

Martin Finkel, DO, medical director, Center for Children's Support, co-conducted two workshops on medical evaluation of child sexual abuse in the primary care office setting for the annual meeting of the American Academy of Pediatrics in Boston.

R. Michael Gallagher, DO, dean, and professor, Family Medicine, presented "Clinical Trials in Headache" at the 16th Annual Practicing Physician's Approach to the Difficult Headache Patient course in Rancho Mirage.

Linda Jones-Hicks, DO, assistant professor, Pediatrics, went on a medical mission to Guatemala City to provide medical care to the underprivileged. The trip was sponsored by Christ Church in Montclair and a church in Guatemala.

Melissa Runyon, PhD, assistant professor, Psychiatry, and Felicia Neubauer, MSW, social worker, Center for Children's Support, co-presented "Treatment of Children and Families at Risk for Child Physical Abuse" at the 8th Annual New Jersey Conference on Child Abuse and Neglect in East Brunswick.

RESEARCH UPDATE

RESEARCHERS REPORT NEW DRUG FOR SYMPTOMS OF PARKINSON’S DISEASE

A new drug seems to improve the quality of life–with minimal side effects–for patients in early stages of Parkinson's disease. A study, conducted at 32 sites nationwide and in Canada with more than 400 participants, reveals that patients who receive rasagiline have improved motor and cognitive skills and are less impaired in their ability to perform daily living tasks. The research is published in the Archives of Neurology, December 2002.

Lawrence I. Golbe, MD, professor and acting chair of the Department of Neurology at RWJMS, who led the RWJMS participation in the study, says these results of the Parkinson's Study Group (PSG) are important "because they indicate rasagiline is safe and well tolerated and this gives us a useful new treatment option for patients in the early stages of the disease."

Rasagiline–a selective irreversible second-generation inhibitor of the enzyme monoamine oxidase Type B–was tested for six months. Patients were given either one or two mg a day of the drug or a placebo.

Each group started the trial with an average score of 25 points on the Unified Parkinson's Disease Rating Scale (UPDRS). Over the first month of the study, patients on one milligram of rasagiline improved by an average of one point, and by the end of the study had worsened by one-tenth of a point. Patients on the placebo showed no measurable change by the end of the first month and by six months had worsened by 3.9 points.

Golbe and his team are now part of a second project evaluating the effects of rasagiline on patients with more advanced Parkinson's disease. The study is sponsored by Teva Neuroscience, a pharmaceutical company based in Israel.

Diana Schlesinger, MD, clinical assistant professor, and Jacqueline Kaari, DO, assistant professor, Pediatrics, presented "Managing Pediatric Asthma So That You and Your Child Can Breathe Easier" at Kennedy Memorial Hospitals–University Medical Center.

Honors:

Lori Feldman-Winter, MD, associate professor, Pediatrics, was accepted as a Fellow of the Academy of Breastfeeding Medicine

RWJMS
Robert Wood Johnson Medical School

Publications:

Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 2nd edition, by Joseph Parrillo, MD, and Richard Dellinger, MD, professors, Medicine, was published by Mosby, St. Louis, 2002.

"Junctional Membrane Structure and Store-Operate Ca Entry in Muscle Cells," by Jianje Ma, PhD, professor, and Zui Pan, PhD, assistant professor, Physiology and Biophysics, was in Frontiers in Bioscience, Vol. 8, 2003.

"Should Patients in Intensive Care Units Receive Erythropoietin?" by Jeffrey Carson, MD, Richard C. Reynolds Professor of Medicine and chief, Division of General and Internal Medicine, was in JAMA, Vol. 28, 2002.

"Radiotherapy vs. Chemotherapy Plus Radiotherapy in Surgically Treated IIIA N2 Non Small Cell Lung Cancer," by Parvesh Kumar, MD, professor and chair, Radiation Oncology, CINJ, was in Clinical Lung Cancer, Vol. 4, 2002.

"Reactivity and Regulation in Cortisol and Behavioral Responses to Stress," by Douglas Ramsay, PhD, associate professor, Pediatrics, and Michael Lewis, PhD, University Distinguished Professor, was in Child Development, Vol. 74, No. 2.

Grants:

Gary Brewer, PhD, associate professor, Molecular Genetics, Microbiology and Immunology, received a three-year, $466,500 grant from the Department of Defense Breast Cancer Research Program to study "RNA-binding Proteins as Novel Oncopro-teins and Tumor Suppressors in Breast Cancer."

Roy Goldfarb, PhD, professor, Medicine, received a one-year, $464,000 grant from Glaxo Smith Kline to study the "Effect of Protein Free Phospholipid Emulsion Therapy in Fatal Porcine Gram Positive Sepsis."

William Vega, PhD, professor, Psychiatry, received a three-year, $1,235,677 grant from the Substance Abuse and Mental Health Services Administration for a "Workforce Training Grant to Reduce Racial and Ethnic Disparities in Mental Health Services."

Melvin Weinstein, MD, professor, Medicine, received a one-year, $104,320 grant from Becton Dickinson and Company for the "Evaluation of Phoenix Automated Microbiology Systems for Susceptibility Testing."

Douglas Ziedonis, MD, PhD, associate professor, Psychiatry, and Jonathan Krejci, PhD, instructor, Psychiatry, received a three-year, $931,274 grant from the National Institute of Drug Abuse to study "Modifying Motivational Enhancement Therapy for Use with Addiction Severity Index."

BOOK REVIEW

THE ENCYCLOPEDIA OF CANCER, SECOND EDITION EDITED BY JOSEPH R. BERTINO, MD
ACADEMIC PRESS

Since the publication of the first edition of The Encyclopedia of Cancer six years ago, a tremendous amount of new information has been generated in this field. This four-volume set includes 220 articles on a very wide range of topics, including molecular biology, immunology, genetics, epidemiology, gene therapy, pharmacology, radiation therapy, biology, and virology. It covers all aspects of cancer, from the basic science to clinical care, providing an overview of the field for medical practitioners; most articles are also accessible to educated lay persons. Editor-in-chief Joseph R. Bertino, MD, assembled an international team of several hundred scientists currently working in the field to write the signed articles in the encyclopedia. Hundreds of illustrations and tables augment the text.

About the editor: Joseph R. Bertino, MD, is an associate director at The Cancer Institute of New Jersey, and University Professor of Medicine and Pharmacology at UMDNJ-Robert Wood Johnson Medical School. He has received several awards and honors, including the Rosenthal Award from the American Association of Clinical Research, the Karnofsky Award from the American Society for Clinical Oncology, and the American Cancer Society Medal of Honor.

Professional Activities:

Dennis Carmody, PhD, professor, Pediatrics, presented "Brain Activity During Auditory Name Recognition: A Functional MRI Study" at a Biomedical Imaging Research Opportunities Workshop in Bethesda.

Rido Cha, MD, associate professor, Medicine, presented "Current Management of Congestive Heart Failure" at the Korean-American Medical Association 20th Annual Convention and Scientific meeting in Litchfield Park, Arizona.Richard Dellinger, MD, professor, Medicine, presented "Supportive Therapies of Severe Sepsis: What Works and What Doesn't" to the Peruvian Society of Intensive Medicine in Lima.

Carl Hochhauser, PsyD, post-doctoral fellow, presented "Pediatric Psychosocial Oncology" at the Albert Einstein College of Medicine, New York.

Michael Lewis, PhD, University Distinguished Professor of Pediatrics and Psychiatry, presented "Developmental Paths to Sexual Intercourse" at a symposium in Havana, Cuba.

SHRP
School of Health Related Professions

Publications:

"Sit-to-Stand Ability Following Ankle Joint Mobilizations in a Patient with Hemiplegia," by Patricia Gillardon, MPT, and Genevieve Pinto-Zipp, adjunct faculty, Master in Physical Therapy Program, was in Neurology Report, Vol. 26, No. 4.

Professional Activities:

Robin Eubanks, MA, clinical assistant professor, Interdisciplinary Studies, presented "Securing Your Future in the Health Professions" at the Associated Medical Schools of New York.

Jill Reichman, MPH, PA-C, associate professor, Matthew McQuillan, MD, PA-C, assistant professor, and Clair O'Connell, MPH, PA-C, associate professor, Physician Assistant Program, Piscataway, presented "Using Literature to Enhance Cultural Competency" at the Association of Physician Assistant Programs, Annual Education Forum in Miami.

Honors:

Riva Touger-Decker, PhD, RD, associate professor and program director, Master in Science in Clinical Nutrition Program, received the American Society of Clinical Nutrition–Dannon Institute Award for excellence in medical/dental nutrition education.

RESEARCH GRANT

GRANT GIVEN TO ESTABLISH GENETIC APPROACH TO UNDERSTANDING CANCERS

Honghua Li, PhD, associate professor in the Department of Molecular Genetics & Microbiology and Immunology at UMDNJ-Robert Wood Johnson Medical School, and a member of The Cancer Institute of New Jersey, has been awarded a $1,965,184 grant from the National Cancer Institute for a study entitled "A Genetic Approach to Genomescale Analysis for Cancers."

Cancer development is caused by genetic alterations affecting the function of a number of genes. This project will try to develop a highly efficient and cost-effective genetic approach to genome-scale analysis of cancers.

It will start with 12,000 genetic markers consisting of single nucleotide polymorphisms that will be incorporated into a high-throughput multiplex genotyping system. Fewer than 10 assays will be sufficient for typing these markers. This system will be used for identifying chromosomal regions that may harbor tumor suppressor genes, and for revealing at least part of the regions that may contain protooncogenes in breast cancer.

"The success of this project will make the high-throughput techniques available for genome-scale analysis of cancers," says Li. "This will make many large-scale genetic studies that may need hundreds of years to complete (if the single marker-base assays are used) take only one or very few years with this high-throughput approach."

The project may also generate highly simplified and affordable experimental procedures for genome-scale analysis of breast cancer, which currently is technically challenging and not affordable for many laboratories.

 

BOOK REVIEW

GENE THERAPY OF CANCER:
TRANSLATIONAL APPROACHES FROM PRECLINICAL STUDIES TO CLINICAL IMPLEMENTATION,
SECOND EDITION

Edited by Edmund C.Lattime, PhD, and
Stanton L. Gerson, MD
Academic Press

This second edition of Gene Therapy of Cancer provides critical updates on the basic science, ongoing research and state-of-art technology in gene therapy. The clinical chapters include new areas of research and successful trials and emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications.

The book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer, providing in-depth descriptions of targeted systems and treatment strategies, explaining the underlying cancer biology necessary for understanding a given therapeutic approach, and covering immune therapeutics of vaccines, cytokines, and peptide-induced responses. It also includes detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference.

About the authors: Edmund C. Lattime, PhD, is a professor of surgery at UMDNJ-Robert Wood Johnson Medical School, and associate director for educational training at The Cancer Institute of New Jersey. He was given a Young Investigator Award from the National Cancer Institute and a Scholar Award from the Leukemia Society of America. Stanton Gerson, MD, is chief of the Division of Hematology/ Oncology at Case Western Reserve University.

 


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