Special Index

Fall Table of Contents

UMDNJ MATTERS

NJMS | SPH | SOM | NJDS | SHRP | UBHC | RWJMS | GSBS | SN

NEW JERSEY MEDICAL SCHOOL

Publications: "A Method to Minimize Indwelling Catheter Calcification and Bladder Stones in Individuals with Spinal Cord Injury," co-authored by Yong Park, MD, resident, and Todd Linsenmeyer, MD, assistant professor, Physical Medicine and Rehabilitation, was in the Journal of Spinal Cord Medicine, Vol. 24, No. 2, 2001.

"A Randomized Efficacy and Feasibility Study of Imagery in Acute Stroke," co-authored by Stephen Page, PhD, assistant professor, Peter Levine, MD, resident, Sue Ann Sisto, MD, assistant professor, and Mark Johnston, PhD, associate professor, Physical Medicine and Rehabilitation, was in Clinical Re-habilitation, Vol. 82, August 2001.

"Autonomic Dysreflexia and Foot and Ankle Surgery," co-authored by Steven Kirshblum, MD, associate professor, and Todd Linsenmeyer, MD, assistant professor, Physical Medicine and Rehabilitation, was in the Journal of Foot and Ankle Surgery, Vol. 40, No. 3, May/June 2001.

"Chronic Fatigue Syndrome and Neuropsychology: An Introduction and Historical Perspective," by John DeLuca, PhD, associate professor, Physical Medicine and Rehabilitation, was in Applied Neuropsychology, Vol. 8, No. 1, 2001.

"Factors Associated with Balance Deficits on Admission to Rehabilitation After Traumatic Brain Injury: A Multicenter Analysis," co-authored by Brian Greenwald, MD, assistant professor, Physical Medicine and Rehabilitation, was in the Journal of Head Trauma Rehabilitation, Vol. 16, No. 3, 2001.

"Functional Status and Mood in Persian Gulf Veterans with Unexplained Fatiguing Illness,"co-authored by John DeLuca, PhD, associate professor, Physical Medicine and Rehabilitation, was in Military Psychology, Vol. 2, No. 4, 2000.

"Impaired Delay Eyeblink Classical Conditioning in Individuals with Anterograde Amnesia Resulting From Anterior Communicating Artery Aneurysm Rupture," co-authored by John DeLuca, PhD, associate professor, and Maria Schultheis, PhD, assistant professor, Physical Medicine and Rehabilitation, was in Behavioral Neuroscience, Vol. 115, No. 3, 2001.

"Longitudinal Assessment of Neuropsychological Functioning, Psychiatric Status, Functional Disability and Employment Status in Chronic Fatigue Syndrome," co-authored by Lana Tiersky, MD, assistant professor, and John DeLuca, PhD, associate professor, Physical Medicine and Rehabilitation, was in Applied Neuropsychology, Vol. 8, No. 1, 2001.

"Mental Practice Combines with Physical Practice for Upper-Limb Motor Deficit in Subacute Stroke," co-authored by Stephen Page, PhD, Sue Ann Sisto, MD, assistant professors, and Mark Johnston, PhD, associate professor, Physical Medicine and Rehabilitation, was in Physical Therapy, Vol. 81, No. 8, August 2001.

"Quantitative Assessment of Cerebral Ventricular Volumes in Chronic Fatigue Syndrome," co-authored by John DeLuca, PhD, associate professor, Physical Medicine and Rehabilitation, was in Applied Neuropsychology, Vol. 8, No. 1, 2001.

RESEARCH NEWS

FUNDING FOR SPINAL CORD INJURY STUDY

The U.S. Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service, has awarded a three-year, $696,000 federal grant to Hosea F.S. Huang, PhD, a research physiologist at the V.A. Medical Center, East Orange, and adjunct associate professor of surgery at New Jersey Medical School, for "Preservation of Sperm Function After Spinal Cord Injury." He also received a $192,053 basic science grant for "Impaired Spermatogenesis After Spinal Cord Injury" from The New Jersey Commission on Spinal Cord Research.

Both studies are examining the effects of spinal cord injury (SCI) on various aspects of the male reproductive system. Infertility is a major consequence of SCI. Although semen can be obtained from more than 90 percent of men with these injuries, full term pregnancy results in less than 5 percent of cases due to poor semen quality. These studies will look at correlations between the extent of SCI and testicular function, and will examine the mechanisms that lead to changes in testicular function after SCI, as well as the response of male accessory glands to androgen. The goal is to offer a simple and inexpensive therapeutic treatment option.

The New Jersey Commission on Spinal Cord Research also awarded a $200,000 basic science grant to Stella Elkabes, PhD, an assistant professor in the Department of Neurosciences, for "Microglia-Neuron Interactions in Spinal Cord Injury." The beneficial and deleterious effects of microglia and their interactions with neurons in spinal cord injury will be studied. Emerging evidence indicates that one of the inflammatory cell types – microglia/macrophages – plays an important role in traumatic nervous system injury and in other pathological conditions. The goal is to elucidate the role of microglia/macrophages in SCI using a rat model.

"Relationship Between Hip Muscle Imbalance and Occurrence of Low Back Pain in Collegiate Athletes," co-authored by Scott Nadler, DO, Joseph Feinberg, MD, assistant

professors, Todd Stitik, MD, associate professor, and Melissa DePrince, MS, research assistant, Physical Medicine and Rehabilitation, was in the American Journal of Physical Medicine and Rehabilitation, Vol. 80, No. 8, 2001.

"Spasticity Management in Traumatic Brain Injury," co-authored by Elie Elovic, MD, assistant professor, Physical Medicine and Rehabilitation, was in Physical Medicine and Rehabilitation: State of the Art Reviews, Vol. 15, No. 2, June 2001.

"The Spontaneous Healing of a Torn Anterior Cruciate Ligament,"

co-authored by Gerard Malanga, MD, James Giradi, MD, and Scott Nadler, DO, assistant professors, Physical Medicine and Rehabilitation, was in the Clinical Journal of Sports Medicine, Vol. 11, 2001.

"Using Early Neuropsychologic Testing to Predict Long-Term Productivity Outcome From Traumatic Brain Injury," co-authored by Scott Millis, PhD, associate professor, and Mitchell Rosenthal, PhD, professor, Physical Medicine and Rehabilitation, was in Archives of Physical Medicine and Rehabilitation, Vol. 82, June 2001.

Grants:

Denise Campagnolo, MD, MS, associate professor, Physical Medicine and Rehabilitation, received a three-year, $233,765 grant from the Spinal Cord Research Foundation for "Factors That Contribute to Infections During Spinal Cord Injury Rehabilitation."

Cheryl Kennedy, MD, assistant professor, Psychiatry and Preventive Medicine and Community Health, received a one-year, $109,000 grant from the HealthCare Foundation of NJ to study "Quality of Life While Aging."

Sue Ann Sisto, PhD, assistant professor, and Steven Kirshblum, MD, associate professor, Physical Medicine and Rehabilitation, received a five-year, $382,523 grant from the National Institute on Disability and Rehabilitation Research for "The Prevalence, Management and Maintenance of Weight Loss in Overweight and Obese Individuals with Chronic Spinal Cord Injury."

Professional Activities:

Hosea F.S. Huang, PhD, adjunctassociate professor, Surgery, Division of Urology, presented "Alteration of the Expression of RAR-y in Human Prostate Adenocarcinoma: Its Correlation with Gleason Staging" at the 2001 Annual Retreat on Cancer Research in New Jersey in Princeton, sponsored by CINJ and the New Jersey State Commission on Cancer Research. He also presented "Altered CREM Localization in Spermatogenic Cells in Testosterone-treated Spinal Cord Injured Rats."

Honors:

Junichi Sadoshima, MD, PhD, associate professor, Medicine, received the American Heart Association’s Cardiovascular Research Prize at the Scientific Conference on Molecular, Integrative, and Clinical Approaches to Myocardial Ischemia in Seattle.

Jennifer Solomon, MD, resident, Physical Medicine and Rehabilitation, was appointed to a two-year term as a member of the Organization of Resident Representatives of the Association of American Medical Colleges.

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SCHOOL OF PUBLIC HEALTH

Publications:

"Association of Maternal Fever During Labor with Neonatal and Infant Morbidity and Mortality," co-authored by Kitaw Demissie, MD, PhD, assistant professor, Epidemiology Division, George Rhoads, MD, MPH, associate dean, Piscataway/New Brunswick, Stephen Marcella, MD, MPH, and Cande Ananth, PhD, assistant professors, Epidemiology Division, was in Obstetrics and Gynecology, Vol. 98, 2001.

RESEARCH NEWS

Audrey R. Gotsch, DrPH, CHES, dean of UMDNJ-School of Public Health, has been awarded a three-year, $971,192 federal grant from the National Center for Research Resources at the NIH, through its Science Education Partnership Award Program. The funding will be used for the Environmental Health Sciences Training and Education Program, an initiative for K-12th grade teachers. The program offers a curriculum prepared by the Environmental and Occupational Health Sciences Institute (EOHSI), a collaboration between UMDNJ and Rutgers, with seven other National Institute of Environmental Health Sciences (NIEHS) Community Outreach and Education Programs nationwide. More than 40,000 K-12th grade students and 2,000 K-12th grade teachers will participate.

Gotsch also received a seven-year, $1,880,838 federal grant from the National Institute of Environmental Health Sciences (NIEHS) for the SUC2ES2 program (Students Understanding Critical Connections between the Environment, Society and Self). It will develop an environmental health sciences curriculum through a teacher training partnership with the Woodbridge Township School District. It is one of only nine initiatives nationwide to receive funding under the NIEHS Integrative Context for Environmental Health Scie Learning Program.

"Expression May Correlate with Stage of Progression in Melanoma," co-authored by Weichung Joe Shih, PhD, professor and director, Biometrics Division, was in Journal of Surgical Research, Vol. 98, 2001.

"Inhibitory Effects of Orally Administered Green Tea, Black Tea, and Caffeine on Skin Carcinogenesis in Mice Previously Treated with Ultraviolet B Light (high-risk mice): Relationship to Decreased Tissue Fat," co-authored by Yong Lin, PhD, assistant professor, and Weichung Joe Shih, PhD, professor and director, Biometrics Division, was in Cancer Research, Vol. 61, 2001.

"Placental Abruption Among Singleton and Twin Births in the United States: Risk Factor Profiles," co-authored by Cande Ananth, PhD, and Kitaw Demissie, MD, PhD, assistant professors, Epidemiology Division, was in American Journal of Epidemiology, Vol. 153, 2001.

"Placental Abruption and Perinatal Mortality in the United States," co-authored by Cande Ananth, PhD, assistant professor, Epidemiology Division, was in American Journal of Epidemiology, Vol. 153, 2001.

Dr. Ananth also co-authored "New Jersey’s Electronic Birth Certificate Program: Variations in Data Sources," which was in the American Journal of Public Health, Vol. 91, 2001.

Grants:

Jun-Yan Hung, PhD, associate professor, Environmental and Occupational Health Division, received a two-year, $95,000 grant from the New Jersey Governor’s Council on Autism to study "Genetic Polymorphism of Tryptophan Hydroxylase and Predisposition to Autism."

Omowunmi Y.O. Osinubi, MD, assistant professor, Division of Environmental and Occupational Health, received a one-year, $25,000 grant from the National American Lung Association to study "Smoking in Preoperative Patients: An Intervention Study." The American Lung Association of New Jersey matched the grant.

Daniel Wartenberg, MD, professor, Epidemiology Division, received a three-year, $814,413 grant from the National Cancer Institute for "Geographic Tools for Surveillance and Study of Disease."

Stanley Weiss, MD, associate professor, Quantitative Methods, Biostatistics and Epidemiology Division, co-principal, received a one-year, $50,000 grant from Merck for "Clinical Effectiveness of the Chronic Treatment of Asthma After Discharge from the Emergency Department Using a Leukotriene Antagonist." Dr. Weiss is co-principal of the grant.

Professional Activities:

Weichung Joe Shih, PhD, professor and director, Biometrics Division, presented "Controlling Type-1 Error Rate for the Accelerated Approval Program of New Anti-Cancer or Anti-Viral Therapies" at the 2001 American Statistical Association Joint Statistical Meetings in Atlanta.

Honors:

Cande Ananth, PhD, assistant professor, Epidemiology Division, received the 2001 Young Professional National Maternal and Child Health Epidemiology Award from the National Coalition for Excellence in MCH Epidemiology and thirteen National Health Organizations (including the CDC, APHA, ASPH, HRSA, March of Dimes, and American Academy of Pediatrics).

Appointments:

Howard Kipen, MD, MPH,professor, Environmental and Occupational Health Division, was appointed as acting director of education for the Center for the Study of War-Related Issues.

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SCHOOL OF OSTEOPATHIC MEDICINE

Publications:

"SPECT in Focal Enterovirus Encephalitis," co-authored by Gary McAbee, DO, JD, chair, Pediatrics, was in Pediatric Neurology, 2001.

BOOK REVIEW

Medical Evaluation of Child Sexual Abuse:
A Practical Guide, Second Edition edited by Martin A. Finkel, DO, FACOP, FAAP, and Angelo P. Giardino, MD, PhD

This book presents approaches to properly performing and documenting examinations of children and adolescents suspected of experiencing sexual abuse. It offers guidelines for diagnosis, and presents nursing issues related to sexual abuse evaluations, forensic evidence collection and meeting the special needs of adolescent patients. It also covers sexually transmitted diseases in children and adolescents and explains how to handle diagnostic dilemmas, as well as legal and psychological issues.

The book is for physicians, nurses, researchers, advanced students in clinical social work and clinical psychology, as well as professionals in the area of child protection and law enforcement. The editors published a previous work on this subject, entitled The Practical Guide to the Evaluation of Sexual Abuse in the Prepubertal Child.

About the editors: Martin Finkel is an associate professor of pediatrics at the School of Osteopathic Medicine (SOM), and medical director of the Center for Children’s Support. Angelo Giardino is an assistant professor of pediatrics at the University of Pennsylvania’s School of Medicine, and associate chair in the Department of Pediatrics at Children’s Hospital of Philadelphia. Julie Lippman, PsyD, an associate professor of psychiatry at SOM, is also a contributor.

Grants:

The Department of Medicine received a three-year, $350,000 grant from the Health Resources and Services Administration of the U.S. Department of Health and Human Services to develop research programs focusing on HIV prevention, geriatrics, women’s health and end-of-life issues.

Professional Activities:

Esther Deblinger, PhD, associate professor, Psychiatry, and clinical director, Center for Children’s Support, presented "Treating Children Who Have Suffered Sexual Abuse" at the 9th Annual Colloquium of the American Professional Society on the Abuse of Children held in Washington, DC.

Martin Finkel, DO, associate professor, Pediatrics, and medical director, Center for Children’s Support, presented "What Law Enforcement Child Protective Service Professionals Need to Know About the Medical Evaluation of Child Sexual Abuse" and "Diagnostic Dilemmas in the Interpretation of Findings in Child Sexual Abuse" at the National Colloquium on the Abuse of Children, sponsored by the American Professional Society on the Abuse of Children . He also presented "Research on Predictors, Consequences and Characteristics of Child Abuse and Neglect" at the 18th International Society on the Prevention of Child Abuse and Neglect European Conference in Istanbul, Turkey.

R. Michael Gallagher, DO, professor and chair, Clinical Family Medicine, presented "Headache" at the Pain Management Grand Rounds at Northwestern Hospital, Seattle.

Linda Jones-Hicks, DO, director, Division of Adolescent Medicine, Pediatrics, presented "Approaching, Assessing and Maintaining Confidentiality" at the Barry Brown Education Center of the Virtual Health-West Jersey Hospital in Voorhees, sponsored by the Southern New Jersey Perinatal Cooperative.

Julie Lippmann, PsyD, assistant professor, Psychiatry, and director, Evaluation Services for Center for Children’s Support, presented "The Most Difficult Legal and Mental Issues Facing Children of New Jersey," a workshop on evaluating sexual abuse allegations in the context of bitter custody battles.

Gary McAbee, DO, JD, chair, Pediatrics, presented Grand Rounds on "Autism" at Mercy Hospital in Rockville Center, NY.

Loretta Mueller, DO, assistant professor, Clinical Family Medicine, presented "Diagnosis and Management of Migraine" at the Family Medicine board review in Mt. Laurel.

Lori Winter, MD, associate professor, Pediatrics, presented "The Big Day, and Caring For Your Baby" at "Stork’s Nest," an educational program offered to pregnant teenagers in Burlington, sponsored by the March of Dimes, Zeta Phi Beta Sorority, Inc, Zeta Delta Zeta Chapter and the Heureka Center. She also presented Grand Rounds on "Breastfeeding in the 21st Century" at St. Joseph’s Children’s Hospital in Paterson.

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NEW JERSEY DENTAL SCHOOL

Publications:

"Alveolar Distraction: A Possible New Alternative to Bone Grafting," by Nina Lehrhaupt, DMD, clinical associate professor, Periodontics, was in the International Journal of Periodontics Restorative Dentistry, Vol. 21, No. 2, 2001.

"Abrasive Machining of Glass-Infiltrated Alumina with Diamond Burs," co-authored by E. Dianne Rekow, DDS, PhD, professor and chair, Orthodontics, was in Machining Science and Technology, Vol. 5, No. 1, 2001.

"Multifocal Inflammatory Jaw Lesion in a Patient with Uncontrolled Diabetes: A Case Report," by Mahnaz Fatahzadeh, DMD, assistant professor, Oral Pathology, Biology and Diagnostic Sciences, Maano Milles, DDS, professor, Oral and Maxillofacial Surgery, and Deborah Cleveland, DDS, associate professor and division director, Oral Pathology, Biology and Diagnostic Sciences, was in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, Vol. 91, No. 4.

"Neural Control of Tongue Movement with Respect to Respiration and Swallowing," by Andrea Sawczuk, DMD, PhD, and Kristine Mosier, DMD, PhD, both assistant professors, Oral Pathology, Biology and Diagnostic Sciences, was in Critical Reviews in Oral Biology and Medicine, Vol. 12, No. 1, 2001.

"Using Psychological Assessment and Therapeutic Strategies to Enhance Well-Being," by Hillary Broder, PhD, MEd, associate professor, General Dentistry & Community Health, was in the Cleft Palate-Craniofacial Journal, Vol. 38, No. 3, May 2001.

Professional Activities:

Robert Binder, DMD, clinical professor, Orthodontics, presented "Edgewise Orthodontics: Thinking and Working in 3 Dimensions" at
the annual session of the American Association of Orthodontists in Toronto.

Rufus Caine, DDS, MPH, associate professor, Oral Pathology, Biology and Diagnostic Sciences, presented "Periodontal Disease and Coronary Heart Disease" to residents at the Bronx Lebanon Hospital.

Kuang-min Chang, DMD, PhD, associate professor, Periodontics, presented "Anti-hypertensive Medications and Gingival Hyperplasia" to participants at the Mid-Atlantic Expo in Atlantic City.

Cosmo DeSteno, DMD, PhD, professor, Prosthodontics and Biomaterials, presented "Centric Relation, Freeway Space and Occlusal Vertical Dimension – The Role in Defining the Treatment Position" at the Mid-Atlantic Expo in Atlantic City, and was a panel participant for the Preclinical and Clinical Design Discussion Group at the University of Nevada School of Dentistry in Las Vegas.

Anthony Maganzini, DDS, MSD, associate professor, and Kenneth Banasiak and Y.K. Tseng, graduate students, Orthodontics, presented "Profile Esthetic Preferences by National Taiwanese" at the annual session of the American Association of Orthodontists in Toronto.


Richard Pertes, DDS, clinical professor, Oral Pathology, Biology and Diagnostic Sciences, presented "Evaluation and Therapeutic Strategies for Orofacial Pain" at the annual scientific meeting of the Spanish Society of Craniomandibular Dysfunction in Malaga, Spain. He also presented "The Nondental Toothache —Why Dental Treatment Does Not Help" at the International University of Catalonia Dental School in Barcelona.

E. Dianne Rekow, DDS, PhD, professor and chair, Orthodontics, co-presented "A Demographic Study of AAO Members Participating in New Jersey" at the annual session of the American Association of Orthodontists held in Toronto. She also presented "Tissue Engineering for Craniofacial Repair" to orthodontists, orthodontic residents and informatics specialists at the Sidney L. Horowitz Lecture in Orthodontics at Columbia University, and "Edge Chipping During Machining Operations to Shape Dental Ceramics" at the IADR meeting in Chiba, Japan.

Barry Zweig, DDS, professor, Oral and Maxillofacial Surgery, presented "Implant Reconstruction in the Posterior Maxilla" at the 2001 annual session of the American College of Oral and Maxillofacial Surgeons in Las Vegas.

Honors:

Arnold Graham, DDS, clinical professor, General Dentistry and Community Health, was appointed chief examiner for the University of Connecticut and Howard University Schools of Dentistry.

John Jandinski, DMD, professor, Oral Pathology, Biology and Diagnostic Sciences, was reappointed Immunology/HIV reviewer for the Annals of Pharmacology.

Alan Kleinman, DMD, clinical instructor, Oral and Maxillofacial Surgery, was appointed New Jersey delegate to the American Dental Society of Anesthesiology’s annual session held in Boston.

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SCHOOL OF HEALTH RELATED PROFESSIONS

Publications:

"Motor Imagery Ability in Individuals Post-stroke: A Behavioral and Functional Imaging Study," co-authored by Judith Deutsch, PhD, PT, associate professor, Physical Therapy Program, was in Neuroimage, Vol. 13. She also co-authored "Post-Stroke Rehabilitation with the Rutgers Ankle System- A Case Study Presence," in MIT Press, August 2001, "Rehabilitation of Musculoskeletal Injuries Using the Rutgers Ankle Haptic Interface: Three Case Reports," in Eurohaptics, 2001, and "A Stewart Platform-Based System for Ankle Telerehabilitation," in Autonomous Robots, Vol. 10, No. 2.

Professional Activities:

David Kietrys, MD, assistant professor, Master of Physical Therapy Program, presented "Progressive Resistance Exercises" to people with HIV at MANNA’s third annual Food for Thought conference in Philadelphia.

Ellen Mandel, MS, PA-C RD, CDE, assistant professor, Physician Assistant Program, presented "Complications of Type 2 Diabetes" to physician assistants at the American Academy of Physician Assistants’ Annual Conference in Anaheim.

Robert Marsico, MS, assistant professor, Master of Physical Therapy Program, Stratford, presented "Autonomic Responses to Maximal Arm Ergometry in Individuals with Paraplegia" at a symposium on the autonomic nervous system in chronic spinal cord injury at the 47th annual conference of the American Paraplegia Society meeting in Las Vegas.

Appointments:

David Gibson, EdD, dean, was elected a member of the Board of Directors of the Association of Schools of Allied Health Professions for a three year term.

Dennise Krencicki, MA, assistant professor, Master of Physical Therapy Program, Stratford, was appointed to the State Board of Physical Therapy.

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UNIVERSITY BEHAVIORAL HEALTHCARE


Publications:

"A Clinical Dilemma - The Overlap between ADHD and PTSD," co-authored by Charles Cartwright, MD, assistant professor, Psychiatry, NJMS, and medical director, Child and Adolescent Partial Care Services, and Carla D’Aiello, PhD, mental health clinician II, Child and Adolescent Partial Care Services, was in the summer 2001 issue of New Jersey Psychologist.

"Geriatric Psychiatry: A Niche in Demand," by Peter Aupperle, MD, medical director, Brief Treatment/Geriatrics, was in Psychiatric Times, August 2001.

"The Relationship Between Dementia and Elder Abuse," by Andrew Coyne, PhD, director, Accreditation and Standards, was in Geriatric Times, July/August 2001.

Professional Activities:

William Vega, PhD, director, Behavioral Research and Training Institute, presented "Cost Benefit of Drug Treatment" to the Organization of American States in Montego Bay.

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ROBERT WOOD JOHNSON MEDICAL SCHOOL

Publications:

"Comparative Evaluation of Penicillin, Ampicillin, and Imipenem MICS and Susceptibility Breakpoints for Vancomycin-susceptible and Vancomycin-resistant Enterococcus Faecalis and Enterococcus Faecium," by Melvin Weinstein, MD, professor, Medicine and Pathology, and chief, Division of Allergy, Immunology and Infectious Diseases, was in the Journal of Clinical Microbiology, Vol. 39, 2001.

RESEARCH NEWS

The New Jersey Commission on Spinal Cord Research has awarded more than $500,000 in grant monies to the following faculty members at Robert Wood Johnson Medical School:

•Ira B. Black, MD, professor and chair of the Department of Neuroscience and Cell Biology, and director of the Joint Graduate Program in Physiology and Neurobiology of Rutgers University and Robert Wood Johnson Medical School, received a two-year, $200,000 basic science grant for "Transplantation of Adult Bone Marrow Stromal Cell-Derived Neurons to Spinal Cord." This study looks at the genetic and biochemical processes that convert stem cells to neurons. Using a rat model, Black transplants these neurons into normal and injured rat spinal cords. The long-term goal is to achieve recovery of function after spinal cord injury by transplanting these neurons, in combination with specific growth and survival hormones.

•John E. Pintar, PhD, professor in the Department of Neuroscience and Cell Biology, received a two-year, $105,000 basic science grant for "IGFBP-5 Regulation of Motor Neuron Cell Death." The effect of a mutation in the mouse IGFBP-5 gene on injury-induced cell death will be examined. Degeneration of spinal cord neurons following injury is a major health concern. This study will look at the elimination of IGFBP-5, which is normally expressed in spinal motor neurons, if its absence delays the death of these neurons following either acute or chronic spinal cord injury and disease.

•Herbert M. Geller, PhD, professor of pharmacology and neurology, received a two-year, $200,000 basic science grant for "Tenascin-C Domains in Experimental Spinal Cord Injury (SCI)." This study evaluates the potential of parts of the tenascin-C molecule in promoting regeneration of axons in the injured spinal cord. After spinal cord injury, a "glial scar" forms that creates a barrier to growth. Axons grow until they reach this scar, and then are repelled. This study uses a rat model of spinal cord injury to evaluate if tenascin-C domains can increase neuronal growth in the injured spinal cord. The long-term goal of this research is to achieve recovery of function after spinal cord injury by application of substances that limit the formation of the glial scar in combination with growth promoting substances.

"Cytokines, Growth Factors, and Plastic Surgery," co-authored by Gregory Borah, MD, professor and chief, Division of Plastic Surgery, was in Plastic and Reconstructive Surgery, Vol. 108, No. 3, September 2001.

"Dual Recovery Therapy for Schizophrenia and Substance Abuse," by Douglas Ziedonis, MD, associate professor, Psychiatry, and director of the Division of Addiction Psychiatry, and Robert Stern, MD, associate professor, Psychiatry, was in Psychiatric Annals, Vol. 31, 2001.

"Mother-Infant Interaction at 12 Months in Prenatally Cocaine-Exposed Children," by Margaret Bendersky, PhD, professor, Pediatrics, and Michael Lewis, PhD, University Distinguished Professor of Pediatrics and Psychiatry, was in the American Journal of Drug and Alcohol Abuse, Vol. 27, No. 2, 2001.

"Peculiar 2 - Aminopurine Fluorescence Monitors the Dynamics of Open Complex Formation by Bacteriophage T7 RNA Polymerase," by Rajiv Bandwar, PhD, research specialist, and Smita Patel, PhD, associate professor, Biochemistry, was in the Journal of Biological Chemistry, Vol. 276, 2001.

"Temperament, Stress and Soothing," by Douglas Ramsey, PhD, associate professor, Pediatrics, and Michael Lewis, PhD, University Distinguished Professor of Pediatrics and Psychiatry, was in Temperament in Context, Vol. 2, 2001.

"Viral Safety of a Pasteurized, Monoclonal Antibody-purified Factor VIII Concentrate in Previously Untreated Hemophilia A Patients," by Claire Philipp, MD, associate professor, Medicine, was in Hemophilia, Vol. 7, 2001.

Grants:

Alice Gottlieb, MD, PhD, professor, Medicine and director, Clinical Research Center, received two two-year grants from Genentech, Inc: a $209,810 grant to study "Anti-CD11a Administered Subcutaneously to Adults with Moderate to Severe Plaque Psoriasis," and a $769,468 grant to study "Subcutaneously Administered Anti-CD 11a Used in Combination with Topical Psoriasis Therapies for Prolonged Maintenance Treatment ACD2243g."

RESEARCH NEWS

CINJ GETS FEDERAL GRANTS FOR ENVIRONMENTAL PROJECT

A federal appropriation of $750, 000 will go to The Cancer Institute of New Jersey (CINJ) for studying the links between the environment and cancer.

"The question is how do different environmental compounds known to be carcinogenic turn normal cells into cancer cells," says Arnold B. Rabson, MD, associate director for basic science at CINJ, director of the newly-created Division of Cancer Genomics and Molecular Oncology at CINJ, and professor in the Departments of Molecular Genetics and Microbiology, and Pathology, at Robert Wood Johnson Medical School. The research will use a genomic approach to gain a better understanding of the different processes that occur when specific carcinogens are introduced into a cell.

"Our long-term goal is to identify ways to block those processes, which will ultimately help people living in areas where those carcinogens are known to exist," Rabson explains.

The grant is part of the fiscal year 2002 Veterans Affairs-Housing and Urban Development (VA-HUD) Appropriations bill, which passed the U.S. Senate in August.

Masayori Inouye, PhD, professor and chair, Biochemistry, received a five-year, $202,124 grant from NIH to study "Reverse Transcriptase in Prokaryotes."

Peter Lobel, PhD, professor, Pharmacology, and resident member, CABM, received a two-year, $250,000 grant from the Ara Parseghian Medical Research Foundation for "Molecular Characterization of Neimann-Pick C2 Disease."

Claire Philipp, MD, associate professor, Medicine, received a one-year, $140,163 grant for "Screening Bleeding Disorders in Women in Menorrhagia: Epidemiologic and Lab Correlates" and a one-year, $64,581 grant to study "The Hemostatic System in Intrauterine Growth Restriction," both funded by the Association of Teachers of Preventive Medicine and the CDC.

Robert Stern, MD, associate professor, Psychiatry, received a one-year, $179,640 grant from Janssen Pharmaceutical to study "A Randomized, Open-Label, Rater-Blinded Assessment of Optimal Treatment Change Strategy to Risperidone for Patients Intolerant of Olanzapine (Risperidone Rescue Study). " He also received a two-year, $488,200 grant from Bristol-Myers Squibb Pharmaceutical Research Institute to study "A Multi-Center, Randomized, Double-Blind Study of Flexible Doses of Aripiprazole versus Perphenazine in the Treatment of Patients with Treatment-Resistant Schizophrenia."

RESEARCH NEWS

MICHAEL J. FOX FOUNDATION FUNDS PARKINSON'S STUDY

Gail D. Zeevalk, PhD, an associate professor of neurology at Robert Wood Johnson Medical School, received a one-year, $65,000 grant from the Michael J. Fox Foundation for Parkinson’s Research. Her study is entitled "Functional Consequences of Glutathione-Mixed Disulfide Formation in Brain Mitochondria."

According to Zeevalk, the underlying mechanism for the loss of dopamine neurons in Parkinson’s disease remains unclear. Mitochondrial defects and reduced levels of glutathione have been found in the brain regions of patients with Parkinson’s disease.

"Our laboratory, as well as others, has shown a close association between mitochondrial dysfunction and a decrease in glutathione status, which can enhance the loss of dopamine neurons," she explains. She further explains that glutathione serves important roles as an antioxidant. One little studied role is its ability to reversibly bind to proteins to form glutathione-protein-mixed disulfides. This formation has been suggested to regulate activity of some enzymes and to protect vulnerable proteins from oxidative damage by free radicals.

"Conversely, some investigators believe that mixed disulfides may be deleterious to cells by altering protein function," she says.

Her research will examine whether glutathione-protein-mixed disulfides alter mitochondrial activity, and will give insights into cellular events involved in Parkinson’s disease.

Jill Williams, MD, assistant professor, Psychiatry, received a five-year, $849,046 grant from the National Institute on Drug Abuse to study "Nicotine Dependence Treatment in Psychiatric Comorbidity."

James Zheng, PhD, assistant professor, Neuroscience and Cell Biology, received a four-year, $521,412 grant from the National Foundation of Science to study "Ca2+-Signaling in Nerve Growth Cone Guidance." He also received a two-year, $200,000 grant from the NIMH to study "Regulation of Neuronal Migration by Second Messengers."

Professional Activities:

Jeffrey Levine, MD, PhD, assistant professor, Family Medicine, presented "Issues in Reproductive Health" and "Treatment Options for Menopausal Symptoms" at the NJ Academy of Family Physicians/PA Academy of Family Physicians' joint annual meeting and scientific assembly in Philadelphia.

Thomas M. Mariano, PhD, assistant professor of Environmental and Community Medicine, is one of several co-inventors at RWJMS who were awarded U.S. Patent # 6,287,853 for the invention entitled "Accessory Factor Function for Interferon Gamma and Its Receptor."

David Seifer, MD, professor, Obstetrics and Gynecology and Reproductive Sciences, presented "Mitochondrial Deletions in Luteinized Granulosa Cells as a Function of Age in Women Undergoing IVF" at the Gordon Research Conference on The Biology of Aging held in Oxford, England.

Sherry Courtney, MD, associate professor, Pediatrics, presented "Early High Frequency Oscillatory Ventilation vs. Synchronized Intermittent Mandatory Ventilation in Very Low Birth Weight Infants" at the Society for Pediatric Research meeting in Baltimore.

Lawrence Golbe, MD, professor and acting chair, Neurology, presented "Progressive Supranulear Palsy: Visual Diagnosis and Molecular Insights" at a course on movement disorders at the 53rd annual meeting of the American Academy of Neurology in Philadelphia.

Honors:

Sidney Pestka, MD, professor and chair, Molecular Genetics and Microbiology, received the 2001 Milstein Award from the International Society of Interferon and Cytokine Research.

Lawrence Taft, MD, professor, Pediatrics, was granted an award of national recognition for his work for children and families with disabilities. He received the 2001 Arnold J. Capute Award in October at the national meeting of the American Academy of Pediatrics.

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SCHOOL OF NURSING

RESEARCH NEWS

FUNDING FOR PEDIATRIC HIV QUALITY OF LIFE STUDY

Deborah S. Storm, PhD, RN, a clinical associate professor at UMDNJ-School of Nursing (SN), and Director of Research and Evaluation at the François-Xavier Bagnoud Center (FXBC), received a three—year, $1,029,291 federal grant to study "The Quality of Life in Children with HIV Infection." The National Institute of Nursing Research of the NIH funded the grant, which is part of an initiative to increase research collaborations with existing clinical trials.

Using prospective, observational data from the Pediatric AIDS Clinical Trials Group protocol 219 Late Outcomes Study, the researchers will examine quality of life during a time of dramatic improvement in the treatment and clinical outcomes of children with HIV infection. One of the goals of the project is to identify the demographic, social, disease related, and treatment factors associated with quality of life outcomes.

The project involves both SN and New Jersey Medical School (NJMS). Co-investigators are Mary G. Boland, DrPH, RN, Francois-Xavier Bagnoud Professor of Nursing, and Program Director of FXBC; James M. Oleske, MD, MPH, François-Xavier Bagnoud Professor of Pediatrics, Director of the Division of Pulmonary, Allergy, Immunology and Infectious Disease at NJMS, and Medical Director of FXBC; and Joan Skurnick, PhD, associate professor of preventive medicine and community health, also at NJMS.

Appointments:

Joyce Griffin-Sobel, RN, PhD, AOCN, CS, associate professor, was named director of Research for the Society of Gastroenterology Nurses and Associates, based in Chicago. She was also an invited participant for a research workshop on "End of Life Issues in Genetic Illness" at the National Institute of Nursing Research, Bethesda.

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GRADUATE SCHOOL OF BIOMEDICAL SCIENCES

RESEARCH NEWS

STUDENT AWARDED FELLOWSHIP

Tammy A. Castro, a PhD candidate in the Department of Pathology and Laboratory Medicine at the Graduate School of Biomedical Sciences (GSBS), has been selected a New Jersey Minority Academic Careers Dissertation Fellow for the academic year 2001-2002. She was nominated by Henry E. Brezenoff, PhD, acting dean. The fellowship will assist Castro in completing her dissertation,"TNF-Alpha Production by Breast Cancer Cells."

A native of Peru, Castro participated in a summer research program through the Hispanic Center of Excellence at UMDNJ-New Jersey Medical School while an undergraduate at New Jersey City University, where she majored in biology and minored in mathematics.

"It was then that I became interested in research," she says.

Subsequently she enrolled in the GSBS summer research program, where she worked with Gill Diamond, PhD, assistant professor of anatomy, cell biology and injury science at NJMS.

Castro is currently studying whether cytokines (mediators of inflammation and immunity) released by breast cancer cells can affect how the cells metastasize. Her mentor is Marion C. Cohen, PhD, associate professor of pathology and laboratory medicine, and of microbiology and molecular genetics at NJMS.

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