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TB Wonder Drug That Shortens Treatment Span to Be Tested (India)

The Times of India, May 6, 2008, by Kounteya Sinha

Moxifloxacin, a fluoroquinolone antibiotic, may be part of a clinical trial to determine whether the drug increases the TB cure rate and shortens treatment time. The study will recruit 2, 400 new TB patients in over 20 sites in the world. Melvin Spigelman, Director of Research and Development for the Global Alliance for TB Drug Development, said that four sites in South Africa, Zambia, and Tanzania are recruiting patients for the study. Read more [+/-]

Sites in India, China, Hong Kong, and Kenya are being considered. Spigelman stated that moxifloxacin has shown an excellent safety profile and has proven highly effective in clearing TB in four months during phase II trials. Part of the new trial will be to determine whether the drug cures TB faster when it is substituted for existing drugs ethambutol or isoniazid, rather than adding it to the present TB treatment regimen. He noted that the $20 million cost would be funded by the Global TB Alliance and the Bill and Melinda Gates Foundation. The following three sites in India are reported to be under consideration as testing sites for the clinical trial: Christian Medical College, Vellore; TB Research Center, Chennai; and the National TB Institute, Bangalore. The study will be a double-blind, randomized, placebo controlled study.

Cases of Drug-Resistant TB Have Doubled, Study Shows (United Kingdom)

The Guardian, May 2, 2008, by Ian Sample

According to a Health Protection Agency study of 28,620 TB cases in England, Wales, and Northern Ireland, resistant strains of TB nearly doubled between 1998 and 2005. The number of people with TB disease resistant to at least one major drug increased from 170 in 1998 to 336 in 2005. More than 8,000 TB cases were reported in England, Wales, and Northern Ireland in 2007. Read more [+/-]

The number of cases of multidrug-resistant TB rose from 23 to 39 over the same time period. The study, which was published in the British Medical Journal, attributes the increase in resistance to the drug isoniazid to immigration of many TB patients from sub-Saharan Africa and the Indian subcontinent. Michelle Kruijshaar, who led the study, noted that the increases highlight the need for early case detection, rapid testing of drug susceptibility, and improved treatment completion.

 

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