The management of patients infected with M. tuberculosis in the presence of an immunocompromising condition can be complicated and challenging. This web-based seminar which was presented on September 16, 2009, covers screening, diagnosis, treatment, and management of patients who are taking anti-tumor necrosis factor agents (TNF-alpha inhibitors) It consists of an overview of the interaction between TNF-alpha inhibitors and TB infection and disease and review the latest recommendations for physicians prescribing these agents as well as for physicians diagnosing and treating TB in patients already taking TNF-alpha inhibitors.