Pharmacology & Physiology

Selected Publications

MANDAVILLI, B., J. H. SANTOS AND B. VAN HOUTEN. Mitochondrial DNA Repair and

        Aging.   Mutation Research, 509 (2002): 127-151.

 

SANTOS, J. H., L. HUNAKOVA, Y. CHEN, C. BORTNER AND B. VAN HOUTEN.

        Cell-sorting experiments link persistent mitochondrial DNA damage with loss of

         mitochondrial membrane potential and apoptotic cell death. Journal of Biological Chem.

        278 (2003): 1728-1734.

 

INGRAM, J. L., A. B. RICE, J. H. SANTOS, B. VAN HOUTEN AND J. C. BONNER.

        Vanadium-induced HB-EGF Expression in Human Lung Fibroblasts is Oxidant-

         Dependent and Requires MAP Kinases. Am J Physiol Lung Cell Mol Physiol,

         284 (2003): L774-L782.

 

WANG Y-Z. , J. L. INGRAM, D. WALTERS, A. B. RICE, J. H. SANTOS, B. VAN

         HOUTEN AND J. BONNER. Vanadium-induced STAT-1 activation in lung

         myofibroblasts requires H2O2 and p38 MAP kinase. Free Radical Biology and Medicine,

         35 (2003): 845-855.

 

GOPALAKRISHNAN, K., J. H. SANTOS, M. A. GRAZCIEWICZ, W. C. COPELAND, G.

         ISAYA, B. VAN HOUTEN AND M. A. RESNICK. Reduction in frataxin causes

         progressive accumulation of mitochondrial damage Human Molecular Genetics, 24

         (2003): 3331-3342.

 

J. H. SANTOS, J. N. MEYER, M. SKORVAGA, L. A. ANNAB, AND B. VAN HOUTEN.

         Mitochondrial hTERT exacerbates free radical-mediated mitochondrial DNA

         damage. Aging Cell, 3 (2004): 399-411.

 

S. L. CHAN, J. H. SANTOS, J. N. MEYER, B. S. MANDAVILLI, D. L. COOK,C. L.

         McCASH Jr, G. KISSLING, B. VAN HOUTEN, W. C. COPELAND, V.

         E.WALKER, K. L. WITT AND J. B. BISHOP. Mitochondrial toxicity in

         cardiomyocytes of CD-1 mice following perinatal exposure to AZT, 3TC,

         or AZT/3TC in combination. Environmental and Molecular Mutagenesis.

          January 2006 [ pub ahead of print].

 

STUART G R, SANTOS J H, STRAND MK, VAN HOUTEN B, COPELAND

         WC.  Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with

         mutations in DNA polymerase gamma associated with progressive external

         ophthalmoplegia. Hum Mol Genet, 15 (2006):363-374.

 

VAN HOUTEN, B., V. WORSHNER AND J. H. SANTOS. Role of mitochondria in toxic

         stress. DNA Repair, 5 (2006): 145-152.

 

J. H. SANTOS, J. N. MEYER AND B. VAN HOUTEN. Mitochondrial localization of

          telomerase as a determinant for hydrogen peroxide-induced mitochondrial 

          DNA damage and apoptosis. Accepted for publication at Hum Mol Genet.