2008

Krady JK, Lin HW, Liberto CM, Basu A, Kremlev SG, Levison SW. Ciliary neurotrophic factor and interleukin-6 differentially activate microglia. J Neurosci Res. 2008 Jan 23.

2007

Needle E, Piparo K, Cole D, Worrall C, Whitehead I, Mahon G, Goldsmith LT*. 2007. Protein kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but
phosphatidylinositol-3-kinase and mitogen-activated protein kinase
independent. Biol Reprod. 2007 Jul;77(1):147-55. Epub 2007 Mar 28.

Rodriguez PL, Sahay S, Olabisi OO and Whitehead IP* (2007) ROCK I-mediated
activation of NF-kappaB by RhoB. Cell Signal. 19, 2361-2369.

Tibrewal, N, Lu, Tong, Li, Hong, and R. B. Birge* (2007). Biochemical and Biophysical Properties of the Phosphatidylserine receptor gene product. (Epub, Mol Cell
Biochemistry).

Kar, B, Singh, S., Reichman, C, O'Connor, JP, and R. B. Birge* (2007). Pro-apoptotic function of nuclear Crk II adaptor protein. (Epub, Biochemistry).

Hague LK, Hall-Pogar T, Lutz CS*. (2007) In vivo methods to assess
polyadenylation. In, Methods in Molecular Biology, J Wilusz, ed. In press.

Wannemacher KM, Yadav PM, Howells RD*. 2007. A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa opioid receptor in human embryonic kidney 293 cells. Journal of Pharmacology and Experimental Therapeutics, In press.

Greco SJ, Zhou C, Ye JH, Rameshwar P* (2007) An interdisciplinary approach and characterization of neuronal cells transdifferentiated from human mesenchymal stem cells. Stem Cells Dev (in press).

Greco SJ, Rameshwar P (2007) Enhancing effect of IL-1a on neurogenesis from adult human mesenchymal stem cells: Implication for inflammatory mediators in regenerative medicine. J Immunol 179:3342.

Greco SJ, Smirnov S, Murthy R, Rameshwar P* (2007) Synergy between RE-1 Silencer of Transcription (REST) and NFêB in the repression of the neurotransmitter gene Tac1 in human mesenchymal stem cells: Implication for microenvironmental influence on stem cell therapies. J Biol Chem (in press).

Greco SJ, Rameshwar P* (2007) miRNAs regulate synthesis of the
neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells. Proc Nat Acad Sci USA (in press).

Greco SJ, Liu K, Rameshwar P* (2007) Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells (in press).

Katarzyna A. Trzaska, Eldo V. Kuzhikandathil and Pranela Rameshwar* Specification of a Dopaminergic Phenotype from Adult Human Mesenchymal Stem Cells DOI: 10.1634/stemcells.2007-0212
Stem Cells published online Jul 26, 2007;

Wang Q, Young TM, Mathews MB*, Pe'ery T*. Developmental regulators containing the I-mfa domain interact with T cyclins and
Tat and modulate transcription. J Mol Biol. 2007 Mar 30;367(3):630-46. Epub 2007 Jan 12.

Hall-Pogar T, Liang S, Hague LK, Lutz CS* 2007. Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-23' UTR. In press, RNA.

2006

Anthony RM, Urban JF Jr, Alem F, Hamed HA, Rozo CT , Boucher JL, Van Rooijen N, Gause WC*. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med. 2006 Aug;12(8):955-60.

Brown S , Chitravanshi VC, Sapru HN* (2006) Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat. Neuroscience . 2006 Sep 21;

Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM, and Rameshwar P.* (2006) Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon. Blood 107:4817-4824

Chen IY, Lypowy J , Pain J, Sayed D , Grinberg S , Alcendor RR , Sadoshima J*, Abdellatif M* Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol Chem. 2006 Jul 14;281(28):19369-77.

Chi, B., Dickensheets, H.L., Spann, K.M., Alston, M.A., Luongo, C., Dumoutier, L., Huang, J.*, Renauld, J.C., Kotenko, S.V., Roederer, M., Beeler, J.A., Donnelly, R.P., Collins, P.L., and Rabin, R.L. (2006) Alpha and lambda interferon together mediate suppression of CD4 T cells induced by the respiratory syncytial virus. J. Virol., 80, 5032-5040.

Cinco, D.D. , Song, Z., Potian, J., Beuve, A.V., McArdle, J.J. and V.H. Routh*. Glucose, insulin and leptin signaling pathways converge on nitric oxide synthesis in glucose sensing neurons in the ventromedial hypothalamic nucleus. Am. J. Physiol. In press.

Corcoran KE , Patel N, Rameshwar P.* Stromal Derived Growth Factor-1 a : Another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells. J Immunol (In press).

Dayaram, Y.K., M.T. Talaue , N.D. Connell*, and V. Venketaraman. 2006.
Characterization of a glutathione metabolic mutant of M. tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriology 188: 1364-72

Depre C*, Wang L, Sui X, Qiu H, Hong C, Hedhli N , Ginion A, Shah A, Pelat M, Bertrand L, Wagner T, Gaussin V, Vatner SF. H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart. Circ Res. 2006 Feb 3;98(2):280-8.

Depre C*, Wang Q, Yan L, Hedhli N , Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner DE, Vatner SF, Madura K. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation. 2006 Oct 24;114(17):1821-8.

Driscoll Carroll K, Bu W, Spadavecchia S , Lynch S, Marras SA, Tyagi S, and DM Lukac*.  2006. Kaposi's Sarcoma-Associated Herpesvirus Lytic Switch Protein Stimulates DNA Binding of RBP-Jk/CSL to Activate the Notch Pathway. J. Virol. 80:9697-3252

Fritz DT, Liu D, Xu J, Jiang S*, Rogers MB. (2004) Conservation of Bmp2 post-transcriptional regulatory mechanisms.  J Biol Chem.  279: 48950 - 48958.

D T Fritz, S Jiang, J Xu, M Rogers, A Polymorphism in a Conserved Posttranscriptional Regulatory Motif Alters Bne Morphogenetic Potein 2 (BMP2) RNA: Protein Interactions. Mol. Endocrin.   2006 20(7):1574-1586.

Gorski, J.N ., Dunn-Meynell, A.A. and Levin, B.E*., Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2006. 291(3): p. R768-778.

Goverover Y, Genova HM , Hillary FG, Deluca* (2006) The Relationship between Neuropsychological Measures and the Timed Instrumental Activities of Daily Living Task in Multiple Sclerosis. J. Multiple Sclerosis , In Press.

Greco SJ , Trzaska KA , Tang K , Taborga M , Rameshwar P.* Current issues of neurotransmitter production in neurons derived from adult stem cells. Curr Topics in Neuroche m (In press).

Gupta, V.*, Galante, A., Soteropolos, P., Guo, S. and Wagner, B.J. Globel profiling reveals novel glucocorticoid induced changes in gene expression of human lens epithelial cells. Mol. Vis. 11: 1018-1040 (2005)

Hillary, F.G., Genova, H.M. , Chiaravalloti , N.D. , Rypma, B., DeLuca, J.*, Prefrontal Modulation of Working Memory Performance in Brain Injury and Disease. Human Brain Mapping. 2006 Nov;27(11):837-47.

Harris, D, Zhang, Z, Chaubey, B, Pandey, V, Identification of Cellular Factors Associated with the 3’-Nontranslated Region of the Hepatitis C Virus Genome. Molec. & Cell Proteo. 2006;5:1006-1018. 

Hosler, MR, Wang-Su, ST, Wagner, BJ, Role of the Proteasome in TGF-β Signaling in Lens Epithelial Cells. Inves Opthalmol Vis Sci. 2006;47:2045-2052). 

Hu J, Qian J, Borisov O, Pan S, Li Y, Liu T, Deng L, Wannemacher K, Kurnellas M, Patterson C, Elkabes S*, Li H. (2006) Optimized proteomic analysis of a mouse model of cerebellar dysfunction using amine-specific isobaric tags. Proteomics 6: 4321-34.

Izano EA, Sadovskaya I, Vinogradov E, Mulks MH, Velliyagounder K, Ragunath C, Kher WB, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB*. 2007. Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae. Microbial Pathogenesis (in press).

Izano EA, Wang H, Ragunath C, Ramasubbu N, Kaplan JB.* 2007. Detachment and killing of Aggregatibacter actinomycetemcomitans biofilms by dispersin B and SDS. Journal of Dental Research (in press).

Kim DD, Pica AM, Durán RG, Durán RG. Acupuncture Reduces Experimental Renovascular Hypertension Through Mechanisms Involving Nitric Oxide Synthases  Microcirc. 13:577 – 585, DOI: 10.1080/10739680600885210

Kurnellas MP , Lee AK, Li H, Deng L, Ehrlich DJ , Elkabes S*. Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. Mol Cell Neurosci: 2006 Dec 4.

Lasfar, A., Lewis-Antes, A., Smirnov, S.V., Anantha, S., Abushahba, W.*, Tian, B., Reuhl, K. Dickensheets, H., Donnelly, R.P., Raveche, E. and Kotenko, S.V. (2006) Characterization of the Mouse IFN-lambda Ligand-Receptor System: IFN-λs Exhibit Anti-Tumor Activity against B16 Melanoma. Cancer Res., 66, 4468-4477

Lee, D, Obukhov, AG, Shen, Q, Christakos, S, et al. Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38. Cell Cal. 2006;39:475-485. 

Liang S., Lutz C.S.* (2006) p54nrb is a component of the snRNP free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. RNA 12:111-121.

Lin HW , Basu A, Druckman C, Cicchese M, Krady JK, Levison SW*. "Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury." Journal of Neuroinflammation 2006, 3:15

Liu Z, Kostenko EV, Mahon GM , Olabisi OO , Whitehead IP*. Transformation by the Rho-specific guanine nucleotide exchange factor Dbs requires ROCK I-mediated phosphorylation of myosin light chain. J Biol Chem. 2006 Jun 9;281(23):16043-51.

Marcinkowska E, Garay E, Gocek E, Chrobak A, Wang X, Studzinski GP*.  Regulation of C/EBP beta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3.Exp Cell Res. 2006 Jul 1;312(11):2054-65.

Mitchell, JE, Tibrewal, N, Patel, V, Birge, RB, et al. The Phosphatidylserine receptor gene product is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. J Biol Chem. 2006;281: 5718-25. 

Moharita AL, Taborga M, Corcoran KE , Bryan M, Patel PS, Rameshwar P.* (2006) SDF-1 a regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis. Blood 108:3245-52.

Muniz, L, Yehia, G, Pillarisetty, R, Memin, E, Molina, CA, Transcriptional Regulation of Cyclin D2 by the PKA Pathway and Inducible cAMP Early Repressor (ICER) in Granulosa Cells. Biol of Repro. 2006 In Press. 

Olabisi OO , Mahon GM , Kostenko EV, Liu Z, Ozer HL*, Whitehead IP*. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Cancer Res. 2006 Jun 15;66(12):6250-7.

Pan Z., Zhang H., Hague LK, Lee JY, Lutz C.S.*, and Tian B. (2006) An intronic poly(A) site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism. Gene 366: 325-334.

Sharabani H, Izumchenko E, Wang Q, Kreinin R, Steiner M, Barvish Z, Kafka M, Sharoni Y, Levy J, Uskokovic M, Studzinski GP*, Danilenko M. Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int J Cancer. 2006 Jun 15;118 (12):3012-21.

Singh AS, Caplan A, Corcoran KE , Fernandez JS, Preziosi M, Rameshwar P.* (2006) Oncogenic and Metastatic Properties of Preprotachykinin-I and Neurokinin-1 genes. Vascular Pharmacol 45:235-42.

Studzinski GP*, Garay E, Patel R, Zhang J , Wang X. Vitamin D receptor signaling of monocytic differentiation in human leukemia cells: role of MAPK pathways in transcription factor activation. Curr Top Med Chem. 2006;6(12):1267-71.

Taborga M , Corcoran KE , Fernandes N, Ramkissoon SH , Rameshwar P.* G-coupled Protein Receptors and Breast Cancer Progression: Potential Drug Targets. Mini Rev in Medicinal Chem (In press).

Trzaska KA , Rameshwar P.* (2007) Current advances in the treatment of Parkinson's Disease with stem cells. Current Neurovascular Res (In press).

Urbanczyk, J. , Chernysh, O ., Condrescu. M. and Reeves. J.P.* (2006) Sodium-calcium exchange does not require allosteric Ca activation at high cytosolic sodium concentrations. J. Physiol. 575: 693-705.

Wang, Q, Young, TM,  Mathews, MB and Pe’ery, T. The developmental regulator I-mfa interacts with P-TEFb and Tat and modulates HIV-1 transcription. J. of Biol. Chem., 2006 (submitted). 

Wu, Y, Tibrewal, N. Birge, RB, Phosphatidylserine (PS) Recognition by Phagocytes: A view to a Kill. Trend Cell Biol. 2006;16:189-197. 

Yang Z, Covey MV, Bitel CL , Ni L, Jonakait GM, and Levison SW (2006) Sustained neocortical neuronal replacement after neonatal hypoxic/ischemic brain injury (In Press, Annals of Neurology 11/24/2006 )

Zebrowski , DC *, Raph R Alcendor* , Lorrie A Kirshenbaum, Junichi Sadoshima. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. Journal of Molecular and Cellular Cardiology 40, 605-618, 2006. (*Equal contribution)

Zhang Y, Zhang J, Studzinski GP*.  AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells. Cell Cycle. 2006 Feb;5(4):447-51.

Interdisciplinary Program

Brown S, Chitravanshi VC, Sapru HN (2006) Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat. Neuroscience. 2006 Sep 21; [Epub ahead of print] 

Cho KJ, Trzaska KA, Greco SJ, McArdle J, Wang FS, Ye JH, Rameshwar P.* (2005) Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1a. Stem Cells 23:383-391.

Claps CM, Corcoran KE, Cho KJ, Rameshwar P.* (2005) Stromal derived factor-1 as a beacon for stem cell homing in development and injury Current Neurovascular Res 4:319-329.

Corcoran K, Patel PS, Rameshwar P.* (2005) An in vitro method to select malignant cells from surgical biopsies of breast cancer patients. Biol Procedures Online 7:7-15.

Harrison JS, Corcoran KE, Joshi D, Sophacleus C, Rameshwar P.* (2005) Peripheral monocytes and CD4+ cells are potential sources for increased circulating levels of TGF-b and Substance P in autoimmune myelofibrosis. Am J Hematol (In press).

Kostenko EV, Mahon GM, Cheng L, Whitehead IP*. The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.J Biol Chem. 2005 Jan 28;280(4):2807-17. Epub 2004 Nov 5.

Legarda, D., Klein-Patel, M., Yim, S., Yuk, M.H., Diamond, G.* Suppression of NF-B-mediated beta-defensin gene expression in the mammalian airway by the Bordetella type III secretion system. Cell. Microbiol., 7:489-97, 2005.

Martinez SE, Yuan L, Lacza C, Ransom H, Mahon GM, Whitehead IP*, Hake LE. XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation. Mol Biol Cell. 2005 Mar;16(3):1152-64. Epub 2005 Jan 5.

Porter, E. Yang, H., Mulye, S., Cuevas-Preza, G., Murillo, O., Lima, H., Greene, S., Lewis, M., Klein-Patel, M., Diamond, G.*, Chesoni, L., Pudney, J., Gulati, S., Ganz, T., Rice, P.A., Quayle, A.J.  Induction and novel processing of human defensin 5 in the human male urethra during Neisseria gonorrhoea and Chlamydia trachomatis infection. Infect. Immun., 73:4823-4833, 2005.

Preziosi M, Arun S. Singh AS, Corcoran KE, Wong E, Ramkissoon SH, Mukerji I, Rameshwar P.* Parallels among subsets of breast cancer in bone marrow, leukemia and hematopoietic stem cells. Res Global Network  (In press).

Rivas-Santiago, B., Schwander, S.K., Sarabia, C., Diamond, G.*, Klein-Patel, M., Hernandez Pando, R., Ellner, J.J., Sada, E.  Human Beta-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect. Immun., 73:4505-4511, 2005.

Ramkissoon SH, Mainwaring LA, Sloand EM, Young NS, Kajigaya S.  Nonisotopic detection of microRNA using digoxigenin labeled RNA probes. Mol Cell Probes. 2005

Sloand EM, Mainwaring L, Fuhrer M, Ramkissoon S, Risitano AM, Keyvanafar K, Lu J, Basu A, Barrett AJ, Young NS. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood. 2005 Aug 1;106(3):841-51.

Ramkissoon SH, Patel HJ, Taborga M, Rameshwar P. G-protein coupled receptors in haematopoietic disruption. Expert Opin on Biol Therapy (In press)

Department of Biochemistry & Molecular Biology

Hall-Pogar T., Zhang H, Tian B, and Lutz, C.S.* (2005) Alternative polyadenylation of cyclooxygenase-2: Nucl Acids Res 33: 2565-2579.

Department of Pathology

Simmons WJ, Koneru M, Mohindru M, Thomas R, Cutro S, Singh P, DeKruyff RH, Inghirami G, Coyle A, Kim BS, Ponzio NM: Tim-3+ T-bet+ Tumor-specific TH1 cells co-localize with and inhibit development and growth of murine neoplasms. J Immunol. 174:1405-1415, 2005.

Studzinski, GP, Wang, X, Yan, J, Wang, Q, Yingyu, Z, Kutner, A, Harrison, JS.  The rationale for deltanoids in therapy for myeloid leukemia:  role of KSR-MAPK-C/EBP pathway.  J Steroid Biochem & Mol. Biol 2005; Oct;97(1-2):47-55.

Wang, Q,  Harrison JS, Uskokovic, M, Kutner, A, Studzinski, GP.  Translational study of vitamin D differentiation therapy of myeloid leukemia:  effects of the combination with a p38 MAPK inhibitor and an antioxidant.  Leukemia 2005;19(10):1812-7.

Wang, Q, Salman, H, Danilenko, M, Studzinski, P. Cooperation between Antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL-60 cell differentiation through the JNK/AP-1/Egr-1 Pathway J Cell Physiol 2005; Sep;204(3):964-74.

M.D./Ph.D. Program

Shakti H. Ramkissoon, Lori A. Mainwaring, Yoji Ogasawara, Keyvan Keyvanfar, John P. McCoy, Elaine M. Sloand, Sachiko Kajigaya, Neal S. Young. "Hematopoietic-specific microRNA expression in human cells" Leukemia Research 2005 – In press

Ramkissoon SH, Patel HJ, Taborga M, Rameshwar P. G-protein coupled receptors in haematopoietic disruption. Expert Opin on Biol Therapy (In press)

Mukerji I, Ramkissoon SH, Reddy KKR, Rameshwar P.* (2005) Autocrine proliferation of neuroblastoma cells is partly mediated through neurokinin receptors: Relevance to bone metastasis. J. Neuro-Oncology 71:91-98.

Patel H, Ramkissoon SH, Patel PS, Rameshwar P.* (2005) Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-I peptides. Proc Natl Acad Sci USA (Track II) 102:17436-441.

Integrative Neurosciences Graduate Program

Nadine Gaab, Kim, H., Lakshminarayanan, K., Archie, J.J., Gary H. Glover, Tallal, P.* & John D.E. Gabrieli (In Press) Neural Correlates of Rapid Spectro-Temporal Processing in Musicians and Nonmusicians.  The Neurosciences and Music II: From Perception to Performance, Annals of the New York Academy of Sciences, Vol. 1060, edited by Giuliano Avanzini, Luisa Lopez, Stefan Koelsch, and Maria Majno.

Pelletier JG, Apergis-Schoute J, Pare D.  Interaction between amygdala and neocortical inputs in the perirhinal cortex. J Neurophysiol. 4(3):1837-48.

Nicot A, Kurnellas M, Elkabes S.  Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis.  Eur J Neurosci. 2005 May;21(10):2660-70.

Priest Birgit, Murphy BA, Lindia JA, Carmen D, Abbadie C, Ritter AM, Liberator P, Iyer LM, Kash SF, Kohler MG, Kaczorowski GJ, MacIntyre DE, and Martin WJ. Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav 1.9 to sensory transmission and nociceptive behavior. PNAS, 102(26):1-6.

Levin BE and Patterson CM.  Exercising the obese brain: resetting the defended body weight. Endocrinology. 2005 Apr;146(4):1674-5.

Rypma, B., Berger, J.S., Genova, H.M., D‚Esposito, M. Dissociating Age-related Changes in Cognitive Strategy and Neural Efficiency Using Event-related fMRI. Cortex. 2005 Aug;41(4):582-94.

Goverover Y, Genova HM, Hillary FG, Deluca (2006) The Relationship between Neuropsychological Measures and the Timed Instrumental Activities of Daily Living Task in Multiple Sclerosis. J. Multiple Sclerosis, In Press.  

Hillary, F.G., Genova, H.M., Chiaravalloti, N.D.,  Rypma, B., DeLuca, J., Prefrontal Modulation of Working Memory Performance in Brain Injury and Disease. Human Brain Mapping. Accepted.

Hur E, Zaborszky L (2005) Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: A combined retrograde tracing in situ hybridization study. J Comp Neurol 483:351-373 

Li, L., Narayan, K., Pak, E., Pachner, A. R.* (2005) Intrathecal antibody production in a mouse model of Lyme neuroborreliosis. Journal of Neuroimmunology (In press).

Pelletier JG, Likhtik E, Filali M, Pare D. (2005) Lasting increases in basolateral amygdala activity after emotional arousal: implications for facilitated consolidation of emotional memories. Learn Mem. 2005 Mar-Apr;12(2):96-102.

Likhtik E, Pelletier JG, Paz R, Pare D. (2005) Prefrontal control of the amygdala. J Neurosci. 2005 Aug 10;25(32):7429-37.

Lazovic, J., Basu, A., Lin, H-W., Rothstein, R.P., Krady, J.K., Smith, M.B., and Levison, S.W. 2005, Neuroinflammation and both cytotoxic and vasogenic edema are reduced in IL-1 Type I receptors deficient mice conferring neuroprotection. Stroke, 36:2226-2231. 

Lin HW, Basu A, Druckman C, Cicchese M, Krady JK, Levison SW. “Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury.” Journal of Neuroinflammation 2006, 3:15 

J Lazovic, A Basu, H-W Lin, RP Rothstein, JK Krady, MB Smith and SW Levison (2005) Neuroinflammation and Both Cytotoxic and Vasogenic Edema are Reduced in IL-1 Type I Receptor Deficient Mice Conferring Neuroprotection. Stroke 36:2226-2231.

Nicot A, Kurnellas M, Elkabes S.  Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis. Eur J Neurosci. 2005 May;21(10):2660-70.

Samson RD, Pare D. Activity-dependent synaptic plasticity in the central nucleus of the amygdala. J Neurosci. 2005 Feb 16;25(7):1847-55.

Samson RD, Pare D. A spatially structured network of inhibitory and excitatory connections directs impulse traffic within the lateral amygdala.  Neuroscience. 2006 Sep 1;141(3):1599-609. 

Levy, W. B, Sanyal, A., Rodriguez, P., Sullivan, D. W., and Wu, X. B.  The formation of neural codes in the hippocampus: trace conditioning as a prototypical paradigm for studying the random recoding hypothesis.  Biological Cybernetics 92, 409-426 (2005).

Sullivan, D. W. and Levy, W. B  Activity affects trace conditioning performance in a minimal hippocampal model.  Neurocomputing 65-66, 315-321 (2005).

Masters Program

Metz RL, Yehia G, Fernandes H, Donnelly R, Rameshwar P.* (2005) Cloning and characterization of the 5¢ flanking region of the HGFIN gene indicate a cooperative role among p53 and cytokine-mediated transcription factors: Relevance to cell cycle regulation. Cell Cycle 4:78-85.

Ramkissoon SH, Patel HJ, Taborga M, Rameshwar P.* G-protein coupled receptors in haematopoietic disruption. Expert Opin on Biol Therapy (In press)

Claps CM, Corcoran KE, Cho KJ, Rameshwar P.* (2005) Stromal derived factor-1 as a beacon for stem cell homing in development and injury Current Neurovascular Res 4:319-329.

Vishalakumar S, Patel H, Moharita AL, Harrison JS, Rameshwar P.* (2005) The anti-proliferative effect of neurokinin-A on hematopoietic progenitor cells is partly mediated by p53 activating the 5¢ flanking region of neurokinin-2 receptor. Cell Signaling 18:422-432.

Kang HS, Habib M, Chan J, Abavana C, Potian JA, Ponzio NM, Rameshwar P.* (2005) A paradoxical role for IFNγ in the immune properties of mesenchymal stem cells during viral challenge. Exp Hematol 33:796-803.

Department of Pharmacology and Physiology

Gaspers L.D, Pierobon N., Thomas A.P. (2005) Calcium Signalling. In: Signaling pathways in liver diseases. Dufour J.F., Graf R., Claiven P.A., eds.  Springer-Verlag GmbH & Co. KG,  Heidelberg, Germany, 18:211-221

Brini M., Manni S., Pierobon N., Du G.G., Sharma P., MacLennan D.H., Carafoli E. (2005) Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harbouring malignant hyperthermia and central core disease mutations. J. Biol. Chem. 280(15):15380-15389

Brini M, Miuzzo M, Pierobon N, Negro A, Sorgato MC. (2005) The Prion Protein and its paralogue doppel affect calcium signaling in Chinese hamster ovary (CHO) cells. Mol Biol Cell 16:2799-2808

Patel S., Gaspers L.D., Pierobon N., Metzger W., Thomas A.P. (2005) Measuring single cell and subcellular Ca2+ signals. In: Calcium Signaling (2nd ed).  J. W. Putney, Jr. (Ed.), CRC Press, Inc., Boca Raton, Florida.  In Press

McArdle J.J., Sellin L.C., Coakley K.M., Potian J.G., Quinones-Lopez M.C., Rosenfeld C.A., Sultatos L.G., Hognason K.. (2005) Mefloquine inhibits cholinesterases at the mouse neuromuscular junction. Neuropharmacology 49:1132-1139.

McArdle J.J., Sellin L.C., Coakley K.M.,. Potian J.G., Hognason K..  (2005) Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals. Neuropharmacology, In Press.

Hognason K., Coakley K.M., Potian J.G., McArdle J.J. (2005) Actions and interactions of iso-OMPA and mefloquine at the neuromuscular junction of acetylcholinesterase knock-out mice. Neurosci Soc Abstract, 157.11.

Varma S., Lal B.K., Zheng R., Breslin J.W., Saito S., Pappas P.J., Hobson II R.W., Durán W.N.  (2005). Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction. Am J Physiol (Heart Circ Physiol) 289:H1744-H1751.

Wang R., Cruciani-Guglielmacci C., Migrenne S., Magnan C., Cotero V.E., Routh V.H.  (2005) The effects of oleic-acid (OA) on distinct populations of neurons in the hypothalamic arcuate nucleus (ARC) are dependent on extracellular glucose levels.  J. Neurophysiol. In Press.

Boone C.D., Bono K., Potian J.G., McArdle J.J. (2005). Correlation of neuromuscular junction morphology and function in streptozotocin-induced diabetes. Neurosci Soc Abstract, 670.17.

2004

Interdisciplinary Program

Cheng L, Mahon GM, Kostenko EV, Whitehead IP*. Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1. J Biol Chem. 2004 Mar 26;279(13):12786-93. Epub 2003 Dec 30.

Department of Biochemistry & Molecular Biology

McClain, M.T., C.S. Lutz*, K.M. Kaufman, O.Z. Faig, T.F. Gross and J.A. James. (2004) Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. Proc Natl Acad Sci USA 101: 3551-3556.

Department of Integrative Neurosciences

Pelletier, J-G., Apergis, J. and Pare, D., 2004, “Low probability transmission of neocortical and entorhinal impulses through the perirhinal cortex,” J. Neurophysiol., In Press.

Rypma, B., Berger, J.S., Genova, H.M., D’Esposito, M. “Dissociating Age-related Changes in Cognitive Strategy and Neural Efficiency Using Event-related fMRI.” Cortex, In Press.

Gullapalli, V.K., Khodair, M.A., Wang, H., Sugino, I.K., Madreperla, S. and Zarbin, M.A., 2004, “Retinal pigment epithelium and photoreceptor transplantation frontiers (Chapter 151),” In: Ryan SG, ed., Retina 4 th Ed., In Press..

Gullapalli, V.K., I.K. Sugino, Y. Van Patten, S. Shah, M.A. Zarbin. 2004, RPE resurfacing of aged submacular human Bruch’s membrane.  Trans Amer Ophthalmol Soc, In Press.

H. Itaya, V. Gullapalli, I.K. Sugino, M. Tamai, M.A. Zarbin.2004, Iris pigment epithelium attachment to aged submacular human Bruch's membrane. Invest Ophthal Vis Sci, In Press.

V.K. Gullapalli, I.K. Sugino, Y. Van Patten, S. Shah, M.A. Zarbin, 2004, Impaired RPE survival on aged submacular human Bruch’s membrane. Exp Eye Res, In Press.

Hur, E. and Zaborszky L., 2004, Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: A combined retrograde tracing-Vglut2 study. J. Comp Neurol,In Press..

Kang, L., Routh, V.H., Kuzhikandathil, E.V., Gaspers, L.D. and Levin, B.E., 2004, “Physiological and molecular characteristics of rat hypothalamic ventromedial neucleus glucosensing neurons,” Diabetes, 53:549-559.

Cruciani-Guglielmacci, C., Kang, L., Wang, R., Ktorza, A., Levin, B.E., Routh, V.H. and Magnan, C., 2004, “Intracerebral lipid infusion in rat leads to pancreatic b-cell hyperresponsiveness to glucose in relation with identification of fatty acid sensitive neurons in hypothalamic nuclei. Amer. J. Physiol., In Press.

Locke, D., Koreen, I.V., Liu, J.Y. and Harris, A.L. (2004) Reversible pore block of connexin channels by cyclodextrins. J. Biol. Chem., 279: 22883-22892.

Koreen, I.V., Elsayed, W., Liu, Y.J. and Harris, A.L. (2004) Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells. Biochem. J., 383: 111-119.

Kurnellas MP, Nicot A, Shull GE, Elkabes S. Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury, FASEB J, In Press.

 Lee, C.R., Abercrombie, E.D. & Tepper, J.M. 2004 Pallidal control of nigral dopaminergic neuron firing pattern and its relation to extracellular neostriatal dopamine. Neuroscience. In Press.

Mamiya, A. and Nadim, F., 2004, “Dynamic interaction of oscillatory neurons coupled with reciprocally inhibitory depressing synapses acts to stabilize the rhythm period,” J. Neuroscience, 24:5140-5150.

Mattson, B.J., and Morrell, J.I. Preference for cocaine- versus pup-conditioned contexts differentially engages neurons expressing either Fos or CART in lactating, maternal rodents. Submitted to J. of Neuroscience, 2004.

Olazabal, D.E., Abercrombie, E., Rosenblatt, J.S. and Morrell, J.I., 2004, “Dopamine and serotonin content and metabolism in the neural circuit that supports maternal behavior in juvenile and adult rats,” Brain Res. Bull. In Press.

Olazábal, D.E.and Morrell, J.I., 2004,Are the same brain regions that inhibit and stimulate maternal behavior in the adult rat also engaged in the inhibition and stimulation of maternal behavior in the juvenile? Submitted to Behavioral Neuroscience.

Pelletier, J-G. and Pare, D., 2004, “Role of amygdale oscillations in the consolidation of emotional memories,” Biol. Psychiatry, 55:559-562.

Rudolph, M., Pelletier, J-G., Pare, D. and Destexhe, A., 2004, Estimation of synaptic conductances and their variances from intracellular recordings of neocortical neurons in vivo, Neurocomputing, In Press.

Pelletier, J-G., Apergis, J. and Pare, D., 2004, Low probability transmission of neocortical and entorhinal impulses through the perirhinal cortex, J. Neurophysiol., 91:2079-2089.

Pelletier JG, Paré D, 2004, Role of amygdala oscillations in the consolidation of emotional memories, Psychiatry, 55: 559-562.

Frederikse PH, Yun E, Kao HT, Zigler JS, Sun Q and Qazi AS, 2004, Synapsin and Synaptic Vesicle Protein Expression During Embryonic and Post-Natal Lens Fiber Cell Differentiation, Molecular Vision, In Press.

Viard, E. and H.N. Sapru. 2004, Carotid baroreflex in the rat: role of glutamate receptors in the medial subnucleus of the solitary tract. Neuroscience, 126: 785-794.

Wansaw, M.P., and Morrell, J.I., 2004, Plasma levels of cocaine and its major metabolites correlated with locomotor activity after subcutaneous injection across the postpartum period in the female rat, Submitted to Physiology and Behavior.

Kuzhikandathil, E.V., Westrich, L., Bakhos, S. and Pasuit, J., 2004, Identification and characterization of novel properties of the human D3 dopamine receptor, Molecular and Cellular Neuroscience, 26:144-155.

Xie X, Wu G, Lu Z-H, Rohowosky-Kochan C, and Ledeen RW. 2004. Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction. Neurochem. Res. 29:2135-2146.

Kurnellas MP, Nicot A, Shull GE, Elkabes S.  Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord
injury.  FASEB J. 2005 Feb;19(2):298-300. Epub 2004 Dec 2.        

Department of Microbiology & Molecular Genetics

Santhanam, A, Hartely, A., Düvel, K, Broach, J.R. and S. Garrett. 2004. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Euk. Cell, 3:1261-1271.

Eguez, L., Chung, Y-S., Kuchibhatla, A., Paidhungat, M., and S. Garrett. 2004 Yeast Mn 2+ transporter, Smf1p, is regulated by ubiquitin-dependent, vacuolar protein sorting.Genetics, 167:107-117.

Cheng, L., Mahon, G.M., Kostenko, E.V., Whitehead, I.P. 2004 Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1. J. Biol. Chem., 279:12786-12793.

Netterwald J.R., Jones T.R., Britt W.J., Yang S.J., McCrone I.P., Zhu, H. 2004 Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus. J Virol., 78:6688-6691.

Bergman, N., Milone, J., Bates, E.J., Opyrchal, M., Bellofatto, V., Wilusz, J. Assessing messenger RNA decapping in cellular extracts. Methods Mol. Biol. 257:181-192.

White, E.J., Cowan, C., Cande, W.Z., Kaback, D.B. 2004 In vivo analysis of synaptonemal complex formation during yeast meiosis. Genetics, 167:51-63.

Harvey, B.P., Banga, S.S., Ozer, H.L. 2004 Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts. J. Biol. Chem., 279:24889-24898.

Department of Pharmacology and Physiology

Olga Chernysh, Madalina Condrescu, John P. Reeves. Calcium-dependent regulation of calcium efflux by the cardiac sodium/calcium exchanger. Am J Physiol Cell Physiol 287: C797-c806, 2004.

Kang, L., Routh, V.H., Kuzhikandathil, E.V., Gaspers, L.D. and Levin, B.E., 2004, “Physiological and molecular characteristics of rat hypothalamic ventromedial neucleus glucosensing neurons,” Diabetes, 53:549-559.

Cruciani-Guglielmacci, C., Kang, L., Wang, R., Ktorza, A., Levin, B.E., Routh, V.H. and Magnan, C., 2004, “Intracerebral lipid infusion in rat leads to pancreatic b-cell hyperresponsiveness to glucose in relation with identification of fatty acid sensitive neurons in hypothalamic nuclei. Amer. J. Physiol., In Press.

Locke, D., Koreen, I.V., Liu, J.Y. and Harris, A.L. (2004) Reversible pore block of connexin channels by cyclodextrins. J. Biol. Chem., 279: 22883-22892.

Koreen, I.V., Elsayed, W., Liu, Y.J. and Harris, A.L. (2004) Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells. Biochem. J., 383: 111-119.

Kuzhikandathil, E.V., Westrich, L., Bakhos, S. and Pasuit, J., 2004, Identification and characterization of novel properties of the human D3 dopamine receptor, Molecular and Cellular Neuroscience, 26:144-155.

Wang R, Liu X, Hentges ST, Dunn-Meynell AA, Levin BE, Wang W, Routh VH. The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes. 2004 Aug;53(8):1959-65.

2003

Interdisciplinary Program

Reverte CG, Yuan L, Keady BT, Lacza C, Attfield KR, Mahon GM, Freeman B, Whitehead IP, Hake LE. XGef is a CPEB-interacting protein involved in Xenopus oocyte maturation. Dev Biol. 2003 Mar 15;255(2):383-98.

Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J. Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem. 2003 May 16;278(20):18393-400. Epub 2003 Mar 13.

Mahon GM, Wang Y, Korus M, Kostenko E, Cheng L, Sun T, Arlinghaus RB, Whitehead IP. The c-Myc Oncoprotein Interacts with Bcr. Curr Biol. 2003 Mar 4;13(5):437-41.

Department of Biochemistry & Molecular Biology

Faig, O.Z., and C.S. Lutz.* (2003) Novel specificity of anti-U1A autoimmune patient sera. Scand. J. Immunol. 57: 79-84.

Hosler, M.R. and Wagner, B.J. Targeted disruption of specific steps in the ubiquitin-proteasome pathway by oxidation in lens epithelial cells. Intl. J. Biochem. Cell Biol. 35: 685-697 (2003)

Gupta, V. and Wagner, B.J. Expression of the functional glucocorticoid receptor in mouse and human lens epithelial cells. Invest. Ophthalmol. Vis. Sci. 44: 2041-2046 (2003)

Wang-Su, S.-T., McCormack, A.L., Yang, S., Hosler, M.R., Mixon, A., Riviere, M.A., Wilmarth, P.A., Andley,U.P., Garland, D., Li, H., David, L.L., Wagner, B.J.  Proteome Analysis of Lens Epithelia, Fibers, and the HLE B-3 Cell Line. Invest. Ophthalmol. Vis. Sci. 44: 4829-4836 (2003)

Barbara J. Natalizio, Luis C. Muniz, George K. Arhin, Jeffrey Wilusz, and Carol S. Lutz. Upstream Elements Present in the 3'-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation Signals.  The Journal of Biological Chemistry Vol.277, No.45, pp 42733-4270, 2002

Tara M. Young, Qi Wang, Tsafi Pe'ery, and Michael B. Mathews.  The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates PTEFb-dependent transcription. Mol Cell Biol. 2003. 23:6373-84.

Mainul Hoque, Tara M. Young, Ginette Serrero, Michael B. Mathews, and Tsafi Pe'ery.  The growth factor granulin interacts with cyclin T1 and modulates P-TEFb dependent transcription. Mol Cell Biol. 2003. 23:1688-702.

Reichman TW and Mathews MB. RNA Binding and Intramolecular Interactions Modulate the Regulation of Gene Expression by Nuclear Factor 110. RNA 9(5): 543-554, 2003.

Reichman TW, Das K, Hameed M, and Harrison LE. Gangliocytic Paraganglioma: A Rare Duodenal Tumor. Surgical Rounds 27(6): 3 12-316, 2003.

Reichman TW, Parrott A, Fierro-Monti I, Canon DJ, Kao PN, Lee CG, Li H, and Mathews MB. Selective Regulation of Transcription by Nuclear Factor 110, a Member of the NF9O Family of dsRNA Binding Proteins. S Mol Bio 332W: 85-98, 2003.

Reichman TW and Mathews MB. The NF9O Family of dsRNA Binding Proteins: Regulators of Viral and Cellular Function. Nuclear Responses: Gene Expression and Translation, ed. M. Karin (in the Handbook of Cellular Signaling, volume 3, eds. R. Bradshaw and E. Dennis). Elsevier Science/Academic Press. 335-342, 2003.

Harrison LE, Reichman TW, Koneru B, Fisher A, Wilson D, Dela Tone A, Samantha A, and Korogodsky M. Racial Discrepancies in the Outcome of Patients with Hepatocellular Carcinoma. Arch Surg, in press.

Reichman TW, Baramipour P, Barone A, Koneru B, Contractor D, Fisher A, Wilson D, Dela Tone A, Cho KC, Samantha A, and Harrison LE. Hepatitis Status, Child-Pugh Classification, and Serum AFP Levels Predict Survival in Patients Treated with Transarterial Embolization for Unresectable Hepatocellular Carcinoma, submitting for publication.

Reza, S. M., Rosetti, M., Pe'ery, T., Mathews, M. B.  Differential activation of Tat variants and their possible role in HIV-1 postintegration latency. Virology, 310, 141-156 (2003).

Reza, S. M., Shen, L., Rosetti, M., Pe'ery, T., Mathews, M. B.  A
naturally-occurring substitution in human immunodeficiency virus Tat increases
expression of the viral genome. (2003) J.  Virol. 77, 8602-8606 (2003).

Department of Integrative Neurosciences

Hansen KA, Sugino IK, Yagi F, Wang H, Tsukahara I, Gullapalli V, Bennett J, Zarbin MA. Adeno-associated virus encoding green fluorescent protein as a label for retinal pigment epithelium. Invest Ophthalmol Vis Sci 2003;44:772-80

Department of Cell Biology & Molecular Medicine

Liu X, Spolarics Z Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression.
Am J Physiol Cell Physiol. 2003 Nov;285(5):C1036-46. Epub 2003 Jul 02

Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL, Boons GJ, Leibovich SJ. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol. 2003 Aug;163(2):711-21.

Leibovich SJ, Chen JF, Pinhal-Enfield G, Belem PC, Elson G, Rosania A, Ramanathan M, Montesinos C, Jacobson M, Schwarzschild MA, Fink JS, Cronstein B. Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol. 2002 Jun;160(6):2231-44.
Am J Pathol. 2002 Jun;160(6):2231-44.

Yingzi Yue, Jaqueline Lypowy, Nadia Hedhli, and Maha Abdellatif. Ras GTPase-activating Protein Binds to Akt and Is Required for Its Activation. J. Biol. Chem. 2004;279 12883-12889.

Department of Microbiology & Molecular Genetics

Düvel, K., Santhanam, A., Garrett, S., Schneper, L. and J.R. Broach.  2003.  Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Molecular Cell 11 :1467-1478.

Barton, A. B., Su, Y., Lamb, J., Barber, D. and Kaback, D. B. (2003) A
function for subtelomeric DNA in Saccharomyces cerevisiae. Genetics,
165: 929-934.

Koreen, L., Ramaswamy, S.V., Graviss, E.A., Naidich, S., Musser, J.M., Kreiswirth, B.N.. spa Typing method for discriminating among staphylococcus aureus isolates:  implications for use of a single marker to detect genetic micro-and macrovariation.  Journal of Clinical Microbiology, 2004 p. 792-799

Department of Pharmacology and Physiology

Brini M, Coletto L, Pierobon N, Kraev N, Guerini D, Carafoli E., A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells. J Biol Chem. 2003 Jul 4;278(27):24500-8.

Department of Pathology and Laboratory Medicine

Sridharan D, Brown M, Lambert WC, McMahon LW, Lambert MW 2003. Nonerythroid alpha II spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. J Cell Science, 116:823-835.

Lefferts JA, Lambert MW  2003. Fanconi anemia cell lines deficient in aII spectrin express normal   levels of aII spectrin mRNA. Biochem Biophys Res Comm, 307:510-515.

Interdisciplinary Departments

Potian, J., Aviv, H., Ponzio, N., Harrison, J., and Rameshwar, P.  Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens.  The Journal of Immunology, 2003, 171"3426-3434.

2002

Department of Biochemistry & Molecular Biology

Reichman, T.W., Muniz, L., Mathews, M.B.
The RNA Binding Protein Nuclear Factor 90 Functions as Both a Positive and Negative Regulator of Gene Expression in Mammalian Cells. Mol. Cell. Biol., 22, 343-356 (2002).

Arrigo, C.J., Singh, K., Modak, M. J.*.
DNA Polymerase I of Mycobacterium tuberculosis: Functional Role of a conserved aspartate in the hinge joining the M and N Helices. J. Biol. Chem., Vol. 277, Issue 3, 1653-1661, January 18, 2002.

Barletta F, Freedman LP and Christakos S.
Enhanced vitamin D receptor mediated transcription and increased interaction between the vitamin D receptor and DRIP205 by phosphatase inhibition. Mol Endocrinol 16, 301-314, 2002.

Department of Microbiology & Molecular Genetics

Mukherjee, D., Gao, M., O'Connor, J.P., Raijmakers, R., Pruijn, G. Lutz, C.S. and Wilusz, J.* (2002).
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J. 21: 165-174.

Arhin, G.K., M. Boots, P.S. Bagga, C. Milcarek and J. Wilusz*. (2002).
Downstream sequence elements with different affinities for the hnRNP H/H’ protein influence the processing efficiency of mammalian polyadenylation signals. Nucleic Acids Res. 30: 1842-1850.

Bergman, N., M. Opyrchal, E.J. Bates and J. Wilusz* (2002). Analysis of the products of mRNA decapping and 3’-to-5’ decay by denaturing gel electrophoresis. RNA 8: 959-965.

Milone, J., J. Wilusz and V. Bellofatto (2002). Identification of mRNA decapping activities and an ARE-regulated 3’ to 5’ exonuclease activity in trypanosome extracts. Nucleic Acids Res. 30: In Press.

Natalizio, B.J., L.C. Muniz, G.K. Arhin, J. Wilusz and C.S. Lutz. (2002).
Upstream elements present in the 3’UTR of collagen genes influence the processing efficiency of overlapping polyadenylation signals. J. Biol. Chem. 277: In Press (Nov/Dec issue).

Cheng, L., Rossman, K.L., Mahon, G.M., Worthylake, D.K., Korus, M., Sondek, J., Whitehead, I.P.*.
RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity. Mol Cell Biol. 2002 Oct;22(19):6895-905.(2002)

Korus, M., Mahon, G.M., Cheng, L. and Whitehead, I.P.*
p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr. Oncogene. Jul 11;21(30):4601-12.(2002)

Lutchman, M., Kim, A.C., Cheng, L., Whitehead, I.P.,* Oh, SS., Hanspal, M., Boukharov, A.A., Hanada, T. and Chishti, A.H.
Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. Eur J Biochem. 2002 Jan;269(2):638-49.(2002)

Department of Neurosciences

Christoffers KH, Khokhar A, Chaturvedi K, Howells RD.
Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin. Regul Pept. 2002 Apr 15;105(1):9-14.

Department of Pathology and Laboratory Medicine

Wajchman J, Simmons WJ, Klein A, Koneru M and Ponzio NM.
Interleukin-12-induced cytotoxicity against syngeneic B cell lymphomas of SJL/J mice. Leukemia Research. 26:577-590, 2002.

2001

Parker, L.M., Fierro-Monti, I., Reichman, T.W., Gunnery, S., Mathews, M.B.
Double-Stranded RNA Binding Proteins and the Control of Protein Synthesis and Cell Growth. Cold Spring Harbor Symp.Quant Biol. 66, (2001)

Taylor, D. R., Tian, B., Romano, P. R., Hinnebusch, A. G., Lai, M. M. C., Mathews, M. B.* 
Hepatitis C viral envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.  J. Virol., 75, 1265-1273, 2001.

Tian, B. and Mathews, M. B.* 
Functional characterization of and cooperation between the double-stranded RNA binding motifs of the protein kinase PKR.  J. Biol. Chem.,  276, 9936-9944, 2001.

Ramanathan, Y., Rajpara, S. M., Reza, S. M., Lees, E., Shuman, S., Mathews, M. B.*, Pe'ery, T. 
Three RNA polymerase II CTD kinases display distinct substrate preferences. J. Biol. Chem., 276, 10913-10920, 2001

Zhang, F., Romano, P. R., Nagamura-Inoue, T., Tian, B., Dever, T. E., Mathews, M. B.*, Ozato, K., Hinnebusch, A. G. 
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J. Biol. Chem. 276, 24946-24958, 2001.

Deng L, Wang D, de le Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P and Kashanchi F.
Enhancement of the p300 HAT activity by HIV-1 Tat on chromosomal DNA. Virology 289, 312-326, 2001.

Raval-Pandya M, Dhawan P, Barletta F and Christakos S.
YY1 represses vitamin D receptor mediated 25(OH)D3 24-hydroxylase transcription by decreasing the association of activator proteins: relief of repression by CREB-binding protein. Mol Endocrinol 15, 1035-1046, 2001

Rabinovitch A, Suarez-Pinzon W, Sooy K, Strynadka K and Christakos S.
Expression of calbindin D-28k in a pancreatic islet b cell line protects against cytokine-induced apoptosis and necrosis. Endocrinolgy 142, 3649-3655, 2001.

Yang W, Hyllner SJ and Christakos S.
Interrelationship between signal transduction pathways and 1,25(OH)2D3 in UMR osteoblastic cells. Am J Physiol (Endocrinology and Metabolism). 281: E162-E170, 2001.

Department of Pathology &  Laboratory Medicine
 
Sen N¹, Simmons WJ¹, Thomas,RM, Erianne G, Zhang DJ, Jaeggli, NS, Huang C, Xiong X, Tsiagbe VK, Ponzio NM*, Thorbecke GJ. 
META-controlled env-initiated transcripts encoding  superantigens of murine Mtv29 and Mtv7 and their possible role in B cell lymphomagenesis. J. Immunol. 166(9): 5422-9, 2001. ¹Authors contributed equally to the study

Sen N, Simmons WJ, Thomas RM, Erianne G, Zhang DJ, Jaeggli NS, Huang C, Xiong
X, Tsiagbe VK, Ponzio NM and Thorbecke GJ.
META-controlled, env-initiated transcripts encoding superantigens of murine Mtv29 and Mtv7 and their possible role in germinal center B cell lymphomagenesis. J Immunol. 166:5422-5429, 2001

Chong SY, Zhang M, Lin Y-C, Coffman F, Garcia Z, Ponzio NM, and Ravechè E.
The growth regulatory role of B-cell-specific-activator-protein (BSAP) in NZB malignant B-1 cells. Cancer Immunology and Immunotherapy. 50:41-50, 2001.

Thomas RM, Belsito DV, Huang C, Chen Lz LZ, Ormsby I, Simmons WJ, Cowin P, Shaw J, Doetschman T, Thorbecke GJ.
Appearance of Langerhans cells in the epidermis of Tgfb1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2.J Invest Dermatol. 2001 Dec;117(6):1574-80.

Simmons WJ, Simms M, Chiarle R, Mackay F, Tsiagbe VK, Browning J, Inghirami G, Thorbecke GJ.
Induction of germinal centers by MMTV encoded superantigen on B cells. Dev Immunol. 2001;8(3-4):201-11

Department of Microbiology

Veraldi, K.L., Arhin, G.K., Martincic, K., Chung-Gangster, L.H., Wilusz, J.* and Milcarek, C.
HnRNP F influences CstF-64 binding to mRNA precursors in mouse B-cells. Mol. Cell. Biol., 21: 1228-1238. (2001)

Gao, M., Wilusz, C.J., Peltz, S.W., and Wilusz, J.*
A novel mRNA decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J. 20: 1134-1143 (2001)

Wilusz, C.J., M. Gao, C.L. Jones, J. Wilusz* and S.W. Peltz.
Poly(A)-binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts. RNA, 7: 1416-1424 (2001)

Cheng, L. and Goldman, E.*
Reversal of inhibition by the T7 concatemer junction sequence on expression from a downstream T7 promoter. Gene Expr. 9(6):257-64. (2001)

Cheng, L. and Goldman, E.*
Absence of effect of varying Thr-Leu codon pairs on protein synthesis in a T7 system. Biochemistry. 40(20):6102-6.(2001)

Department of Pharmacology and Physiology

Clint Rosenfeld, Ahmed Kousba, and Lester G. Sultatos.
Interactions of Rat Brain Acetylcholinesterase with the Detergent Triton X-100 and the Organophosphate Paraoxon Toxicol. Sci. 63: 208-213 (2001)

Ye, J.-H., L. Tao, J. Ren, R. Schaefer, K. Krnjevic, P.L. Liu, D.A.Schiller, J.J. McArdle*.
Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. Journal of Pharmacology and Experimental Therapeutics 296: 77-83, 2001.

Jiang, L, Ferraris, R.P.* 
Developmental reprogramming of rat GLUT-5 requires de novo mRNA and protein synthesis.  Am. J. Physiol. 280:G113-G120, 2001.

Monteiro, I.M., Jiang, L., Ferraris, R.P.* 
Dietary modulation of intestinal fructose transport and GLUT5 mRNA expression in hypothyroid rat pups.  J. Ped. Gastroenterol. Nutr. 29:563-570, 1999.
 

2000

Department of Anatomy, Cell Biology & Injury Science

Diamond, G.*, Legarda, D., Ryan, L.K.
The innate immune response of the respiratory epithelium. Immun. Rev., 173:27-38, 2000.

Cole, A.M., Darouiche, R.O., Legarda, D., Connell, N., Diamond, G.*
Characterization of a fish antimicrobial peptide: Gene expression, subcellular localization and spectrum of activity. Antimicrob. Agents Chemother., 44:2039-45 2000.

Amy M. Liese, Muhammad Q. Siddiqi, Zoltan Spolarics*.
Rapid detection of glucose-6-phosphate dehydrogenase type A-202A/376G deficiency by allele-specific polymerase chain reaction. American Journal of Hematology 63(3): 159-160 (2000).
 

Department of Biochemistry & Molecular Biology

Tian, B., White, R. J., Xia, T., Welle, S., Turner, D. H., Mathews, M. B*.,
Thornton, C. A.  Expanded CUG repeat RNAs form hairpins that activate the double-stranded-RNA-dependent protein kinase PKR.  RNA 6: 79-87 (2000).

Kirti Chaturvedi, Mandana Shahrestanifar and Richard D. Howells*
mu Opioid receptor: role for the amino terminus as a determinant of ligand binding affinity, Molecular Brain Research 76: 64-72 (2000).

Singh K, Kaushik N, Jin J, Madhusudanan and Modak MJ.
Role of Q190 of MuLV RT in ddNTP resistance and fidelity of DNA synthesis: a molecular model of interactions with substrates. Protein Eng 13, 635-643, 2000.

Kaushik N, Talele T, Pandey PK, Harris D, Yadav PNS and Pandey VN.
Role of glutamine 151 of HIV-1 RT in substrate selection as assessed by site-directed mutagenesis. Biochemistry 39, 2912-2920, 2000.

Kaushik N, Chowdhury K, Pandey VN and Modak MJ.
Valine of the YVDD motif of Moloney murine leukemia virus reverse transcriptase: role in the fidelity of DNA synthesis. Biochemistry 39, 5155-5165, 2000.

Tuske S, Singh K, Kaushik N, and Modak MJ.
The J-helix of E. coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'-5' exonuclease functions.J Biol Chem 275, 23759-23768, 2000.

Deng L, Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Lee CG and Kashanchi F.
Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome, and enhances binding to core histones. Virology 277, 278-295, 2000.

Gary DS, Sooy K, Chan SL, Christakos S and Mattson MP.
Concentration and cell type specific effest of calbindin-D28k on vulnerability of hippocampal neurons to seizure-induced injury. Mol Brain Res 75, 89-95, 2000.

Wang Q, Yang W, Uytingco MS, Christakos S and Wieder R.
1,25 dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death. Cancer Res 60, 2040-2048, 2000.

St. Arnaud R, Arabian A, Travers R, Barletta F, Raval-Pandya M, Chapin K, Christakos S, Demay MB and Glorieux FH.
Impaired vitamin D metabolism affects intramembranous bone formation during development. Endocrinology 141, 2658-2666, 2000.

Sooy K, Kohut J and Christakos S.
The role of calbondin and 1,25 dihydroxyvitamin D3 in the kidney. Current Opinion in Nephrology and Hypertension 9, 341-347, 2000.

Clark E, Santiago F, Deng L, Chong SY, de la Fuente C, Wang L, Fu P, Stein D, Denny T, Lanka V, Mozafari F, Okamoto T and Kashanchi F.
Loss of G1/S checkpoint in human immunodeficiency virus type-1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. J Virol 74, 5040-5042, 2000.

Bellido T, Huening M, Raval-Pandya M, Manolagas SC and Christakos S.
Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. J Biol Chem 275, 26328-26332, 2000.

Christakos S, Barletta F, Huening M, Kohut J and Raval-Pandya M.
Activation of programmed cell death by calcium: protection against cell death by calcium binding protein calbindin-D28k: The Molecular Basis of Calcium Acting in Biology and Medicine (R Pochet, J Huiech, C Heizmann and V Gerke, eds) Kluwer Academic Publishers, The Netherlands pp 259-275, 2000.

Department of Microbiology

Fritz, D.T., Ford, L.P., Wilusz, J.*
An in Vitro Assay to study Regulated mRNA Stability. Science's STKE: http://www.stke.org/cgi/content/full/OC_sigtrans;2000/61/p11 (2000)

Gao, Min, Fritz, D.T., Ford, L.P. and Wilusz, J.*
Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation in vitro. Molecular Cell 5: 479-488 (2000).

Houghton J, Macera-Bloch L, Harrison L, Korah R. (Mentor: Dr. H. Ozer).
TNF-a and IL-1b upregulate gastric mucosal Fas Ag expression in Helicobacter pylori infection. Infection and Immunity 68:1189-1195 (2000).

D'Alessio, Michael and Brandriss, Marjorie C. *
Cross-pathway regulation in Saccharomyces cerevisiae: Activation of the proline utilization pathway by Gal4p in vivo. J. Bacteriol. 182 (13):3748-3753 (2000).

Department of Neurosciences

Kirti Chaturvedi, Xiexu Jiang, Keith H. Christoffers, Norihiro Chinen, Persis Bandari, Luca F. Raveglia, Silvano Ronzoni, Guilio Dondio, Richard D. Howells*
Pharmacological profiles of selective non-peptidic delta opioid receptor ligands. Mol. Brain Res. 80: 166-176, (2000).

K. Chaturvedi, K. Christoffers, K. Singh and R.D. Howells*. 
Down Regulation of Opioid Receptors.  Biopolymers/Peptide Science, 55 (4): 334-346, (2000).

Ingoglia, N.*, Ramanathan, M., Zhang, N., Tseng, B., Mathur, G., Opuni, K. and Donnelly, R.
What is the signal for arginylation? Neurochem. Res. 25: 51-58 (2000).

Department of Pharmacology and Physiology.

Opuni, K. and Reeves, J.P.*
Feedback inhibition of sodium/calcium exchange by mitochondrial calcium accumulation. J. Biol. Chem. 275: 21549-21554.

Szalai, G., Csordas, G., Hantash, B.M., Thomas, A.P.* and Hajnóczky, G.
Calcium signal transmission between ryanodine receptors and mitochondria. J. Biol. Chem. 275, 15305-15313. (2000)

Department of Pathology &  Laboratory Medicine

Erianne G, Wajchman J, Yauch R, Tsiagbe VK, Kim BS and Ponzio NM.
B cell lymphomas of C57L/J mice; the role of Natural Killer cells and T helper cells in lymphoma development and growth. Leukemia Research. 24:705-718, 2000.

1999

Department of Anatomy, Cell Biology & Injury Science

Condon, M.R., Viera, A., D'Alessio, M., Diamond, G.* Induction of a rat enteric defensin gene by hemorrhagic shock. Infect. Immun. 67:4787-93, 1999.

Yount, N.Y., J. Yuan, A. Tarver, T. Castro, G. Diamond, P.A. Tran, J.N. Levy, C. McCullough, J.S. Cullor, C.L. Bevins, and M.E. Selsted Cloning and expression of bovine neutrophil beta-defensins: biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J. Biol. Chem. 274:26249-58, 1999.

W. F. Schmalz, Jr., A. D. Hernandez, and P. Weis*. Hepatic histopathology in two populations of the mummichog, Fundulus heteroclitus. Mar. Environ. Res. (in press). (1999)

Department of Biochemistry & Molecular Biology

Cai, H, Howells, RD, Wagner, BJ. Identification of a novel gene product preferentially expressed in rat lens epithelial cells. Mol. Vis. 5: 3 (1999).

J. Jin, N. Kaushik, K. Singh, M.J. Modak* Analysis of the role of glutamine 190 in the catalytic mechanism of murine leukemia virus revers transcriptase. J. Biol. Chem. 274: 20861-20868 (1999)

Y. Ramanathan, S. M Reza, Tara M Young, Micheal B Mathews*, Tsafi Peery. Human and Rodent Transcription Elongation factor P-TEFb: Interactions with Human Immunodeficiency Virus Type I Tat and Carboxy Terminal Domain Substrate. J Virol 73(7):5448-5458 July 1999.

Jin J, Kaushik N, Singh K and Modak MJ.* Analysis of the role of Gln 190 in the catalytic mechanism of murine leukemia virus reverse transcriptase.J Biol Chem 274, 20861-20868, 1999.

Ramanathan Y, Reza SM, Young TM, Mathews MB, Pe'ery T.* Human and rodent transcription elongation factor P-TEFb: interctions with human immunodeficiency virus type 1 Tat and carboxy-terminal domain substrate. J Virol 73, 5448-5458, 1999.

Yang W, Friedman PA, Kumar R, Omdahl JL, May BK, Siu-Caldera ML, Reddy GS and Christakos S.* Expression of 25(OH)D3 24-hydroxylase in the distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH. Am J Physiol (endocrinology and Metabolism 276: E793-E805, 1999.

Sooy K, Schermerhorn T, Noda M, Surana M, Meyer M, Fleischer N, Sharp GWG, Rhoten WB and Christakos S.* Calbindin-D28k controls [Ca2+]i and insulin release: evidence obtained from b cell lines and calbindin-D28k knock-out mice. J Biol Chem 274, 34343-34349, 1999.

Wernyj R, Mattson MP and Christakos S.* Expression of calbindin-D28k in C6 glioma cells stbilizes intracellular calcium and protects against apoptosis induced by calcium ionophore and amyloid b-peptide. Mol Brain Res 64, 69-79, 1999.

Department of Microbiology and Molecular Genetics

Ford LP and J Wilusz.* 3'-Terminal RNA structures and poly(U) tracts inhibit initiation by a 3'--5' exonuclease in vitro. Nucleic Acids Res. 1999 Feb 15; 27(4):1159-1167.

Luo H, Gilinger G, Mukherjee D, Bellofatto V*. Transcription initiation at the TATA-less spliced leader RNA gene promoter requires at least two DNA-binding proteins and a tripartite architecture that includes an initiator element.J Biol Chem. 1999 274(45): 31947-54

Ford LP, J Watson, JD Keene and J Wilusz*. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev. 1999 Jan 15;13(2):188-201.

Ford LP and J Wilusz.* An in vitro system using Hela cytoplasmic extracts that reproduces regulated mRNA stability. Methods, 17: 21-27.

Yang, C., Theis, J.F., and Newlon, C.S.* Conservation of ARS elements and chromosomal DNA replication origins on chromosomes III of Saccharomyces cerevisiae and S. carlsbergensis. Genetics 152:933-941 (1999).

Theis, J.F., Yang, C., Schaefer, C.B., and Newlon, C.S.* DNA sequence and functional analysis of homologous ARS elements of Saccharomyces cerevisiae and S. carlsbergensis. Genetics 152:943-952 (1999).

B. Harvey, M. Korus and E. Goldman*. The T7 concatemer junction sequence interferes with the expression from a downstream T7 promoter in vivo. Gene Expression 8:141-149.

Department of Neurosciences

Siegel, A.*, T. A.P. Roeling, T. R. Gregg and M.R. Kruk. The neuropharmacology of brain stimulation evoked aggression. Neuroscience & Biobehavioral Reviews, 23:359-389 (1999).

Ramanathan, M., Hassanain, M., Levitt, M., Seth, A., Tolman, S., Fried, V. and Ingoglia, N.* Oxidative stress increases ubiquitin-protein conjugates in rat brain synaptosomes. NeuroReport. 10 #18, 3797-3802 (1999).

E. Mena and C. Rohowsky-Kochan*. Expression of costimulatory molecules on peripheral blood mononuclear cells in multiple sclerosis. Acta Neurol Scand. 1999 Aug; 100(2):92-96.

Program in Experimental Pathology

Brois, D.W., McMahon, L., Ramos, N.I., Anglin, L.M., Walsh, C.E. and Lambert, M.W.* A deficiency in a 230 kDa DNA repair protein in Fanconi anemia complementation group A cells is corrected by the FANCA cDNA. Carcinogenesis 20:1845-1853 (1999).

McMahon, L.W., Walsh, C.E. and Lambert, M.W.* Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J. Biol. Chem. 274:32904-32908 (1999).

Czarneski J, Yi-Chu L, Ende N, Ponzio NM* and Raveche E.* Effects of cord blood transfer on the hematopoietic recovery following sublethal irradiation in MRL lpr/lpr mice. Proc Soc Exp Biol Med. 220:79-87, 1999.

Department of Pharmacology & Physiology

Monteiro IM, Jiang L, Ferraris RP* Dietary modulation of intestinal fructose transport and GLUT5 mRNA expression in hypothyroid rat pups. J Pediatr Gastroenterol Nutr. 29: 563-70 (1999)

Condrescu, M., Hantash, B.M., Fang, Y. and Reeves, J.P.* Mode-specific inhibition of sodium-calcium exchange during protein phosphatase blockade. J. Biol. Chem. 274: 33279-33286.
 

1998

Department of Biochemistry and Molecular Biology

Cai, H., Singh, I. and Wagner, B.J.* Gene expression of the proteasome in rat lens development. Exp. Eye Res. 66: 339-346 (1998).

Harris, D., Lee, R., Misra, H.S., Pandey, P.K., and Pandey, V.N.* The p51 Subunit of Human Immunodeficiency Virus Type1 Reverse Transcriptase is Essential in Loading the p66 Subunit on the Template Primer. Biochemistry 37: 5903-5908 (1998).

Harris D, Kaushik N, Pandey PK, Yadav PNS and Pandey VN.* Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase. J Biol Chem 273, 33624-33634, 1998.

Harris D, Yadav PNS and Pandey VN.* Loss of polymerase activity of human immunodeficiency virus type-1 reverse transcriptase due to Tyr Phe substitution in the YMDD motif is restored by Met Val substitution within the same motif. Biochemistry 37, 9630-9640, 1998.

Raval-Pandya M, Freedman LP, Li H and Christakos S.* The thyroid receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor mediated transactivation. Mol Endocrinol 12, 1367-1379, 1998.

Department of Microbiology and Molecular Genetics

Bagga PS, GK Arhin and J Wilusz.* DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro. Nucleic Acids Res. 1998 Dec 1;26(23):5343-50.

Achal Bhatt, Renee Green, Roswell Coles, Michael Condon and Nancy Connell* A Mutant of Mycobacterium smegmatis Defective in Dipeptide Transport. Journal of bacteriology 180(24):6773-6775, 1998.

Fan Chen and Jeffrey Wilusz* Auxiliary downstream elements are required for efficient polyadenylation of mammalian pre-mRNAs. Nucleic Acids Res. 26: 2891-2898 (1998).

S.-H. Kim, S. Banga, K.K. Tha and H.L. Ozer* SV40-mediated transformation and immortalization of human cells; in Simian Virus (SV40): A possible human polyomavirus. F. Brown & A.M. Lewis (eds). Dev Biol Stand. Vol 94, 1998 (in press).

Cherry Wu, Kerstin Weiss, Chen Yang, Midori A. Harris, Bik-Kwoon Tye, Carol S. Newlon*, Robert T. Simpson, and James E. Haber. Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching. Genes & Development 12:1726-1737 (1998).

Department of Neurosciences

Cheu, J.W. and Siegel, A.* GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat: role of the lateral hypothalamus. Brain Research, 783:293-304 (1998).

G. Wu, Z.-H. Lu, T.J. Wei, R.D. Howells, K. Christoffers, R.W. Ledeen. The role of GM1 ganglioside in regulating excitatory opiod effects. Ann. NY Acad. Sci. 845: 126-138 (1998)

D. Kozireski-Chuback G. Wu, R. Ledeen* Upregulation of nuclear GM1 accompanies axon-like but not dendrite-like outgrowth in NG108-15 cells. J. Neuroscience Res. (1998, in press).

Luo, B., J. Cheu, and A. Siegel* Choleycystokinin B receptors