Fundamentals of Biomedical Sciences I: Biochemistry and Molecular Biology
(Course GSND N500A) - 2008
Fall 2008, Wednesdays, 6:00 to 9:00 p.m. Room B556, Medical Science Bldg.
Instructor: Michael A. Lea, Ph.D., Telephone: 973-972-5345, Fax: 973-972-5594
e-mail lea@umdnj.edu, Office: Room E649
COURSE OUTLINE: This course covers basic biochemistry and molecular biology. The nature of the major macromolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.
WEEK |
DATE |
TOPIC |
DOWNLOADS |
|
1 |
Sept. 3 |
Introduction - Functional Groups in Biological Molecules, Amino Acids |
|
|
2 |
Sept. 10 |
Protein Structure and Function; Enzymes: Kinetics and Regulation |
|
|
4 |
Sept. 17 |
Carbohydrates and Nucleotide Structure, Glycolysis and Gluconeogenesis |
|
|
4 |
Sept. 24 |
Pentose Phosphate Pathway, Glycogen and Glycosaminoglycans |
|
|
5 |
Oct. 1 |
Bioenergetics and the Tricarboxylic Acid Cycle; Electron Transport and Oxidative Phosphorylation |
|
|
6 |
Oct. 8 |
Lipid metabolism and Review |
|
|
7 |
Oct. 15 |
Examination 1 |
|
|
8 |
Oct. 22 |
Amino Acid Metabolism, Protein Turnover and the Urea Cycle
Porphyrins and Hemoglobin |
|
|
9 |
Oct. 29 |
Nucleotide Metabolism and DNA Synthesis |
|
|
10 |
Nov. 5 |
RNA and Protein Synthesis |
|
|
12 |
Nov. 12 |
Techniques in Molecular Biology |
|
|
13 |
Nov. 19 |
Regulation of Gene Expression and Intermediary Metabolism |
|
|
14 |
Nov. 26 |
Thanksgiving Holiday - No Class |
|
|
15 |
Dec. 3 |
Review |
|
|
16 |
Dec. 10 |
Study |
|
|
15 |
Dec. 17 |
Examination 2 |
|
|
Suggested Text: Lippincott’s Illustrated Reviews: Biochemistry, 4th edition, 2007, by P.C. Champe, R.A. Harvey and D.R. Ferrier, published by Lippincott Williams and Wilkins, Philadelphia
Points: Exam 1 and 2, 50% each
Download Instructions:
Some files may be larger then 4 mb and require significant
time to open. It is recommended that the presentations
are saved to hard disk before opening. PC users
right-click on the file and select "Save Target
As...", Mac users hold-click and select "Save
File" or "Copy File". You will then
be prompted to save and select a location for the
file. |
