Certificate Program in Pharmacological Sciences
A certificate in Pharmacological Sciences (15 credits) is achieved by taking four required courses and one elective. Individuals should apply using the non-matriculates and certificate programs application form.
All students are required to take:
GSND N500A Fundamentals of Biomedical Sciences I. Biochemistry and Molecular Biology.
3 cr. Fall
This course is Part I of the evening fundamentals course that is given to Masters Students. This course covers basic biochemistry and molecular biology. The nature of the major macromolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.
GSND N500B Fundamentals of Biomedical Sciences II. Cellular Biology. 3 cr. Spring
This course is Part II of the evening fundamentals course that is given to Masters Students. In this course students are introduced to basic cellular structure and function. Topics include: an introduction to the techniques used for studying cell biology, biomembranes, cell compartments, exocytosis and endocytosis, the nucleus, cell cycle and apoptosis, cell signaling, cytoskeleton, extracellular matrix, angiogenesis, wound repair, cell surface specializations and junctions, and basic tissue biology of epithelia, connective tissue and nerve tissue. The lecture series provides an overview of important concepts in cell biology. Key experiments are described and some of the relevant topics of cell biology in the news are discussed.
PHPY5020 Principles of Pharmacology. 3 cr. Fall
The quantitative aspects of dose effect relationships, drug antagonism and specificity of drugs for effector systems are considered. Laboratory exercises are included.
PHPY N5030 Topics in Pharmacology. 3 cr. Spring
This course will cover a few selected areas in pharmacology. Drugs used in treatment of central nervous system disorders, endocrine clinical problems and chemotherapy. Textbooks: Goodman & Gilman’s “The Pharmacologic Basics of Therapeutics” and Katzung’s “Basic and Clinical Pharmacology.” Jan-May
Students choose any one of the following courses:
PHPY N5225 Principles of Toxicology, 3 cr. Fall
This interdisciplinary course will survey the principles of toxicology that pertain to human health. Course content will include an historical background of toxicology and classroom instruction on organ and physiologic system dysfunction following exposure to toxic agents with emphasis on diagnostic techniques. Selected topics include: genotoxicity; carcinogenicity; teratology, toxicity of the central nervous; reproductive, respiratory and hematological systems; hepatic, renal, dermal and ocular toxicity. Presentation: an evidence oriented approach; material is presented through a series of lectures, small group discussions and self-study modules.
PATH N5209 The Business of Science: Drug Development – Discovery to Market. 3 cr. Fall
The goals of this course are to survey the basic concepts and strategies for drug discovery and development, with an emphasis on practical applications rather than theory; provide in-depth consideration of the key phases of pre-clinical drug discovery; examine the impact of rapidly changing “disruptive technologies” on the processes of drug discovery; study the basic design and conduct of phase 1-4 clinical trials; provide a forum for discussion of practical considerations of careers in drug discovery/development; and provide and opportunity for practical application of concepts.
GSND N5310 Clinical Trials Overview: Methodology and Practice. 3cr. Spring
This course is designed to teach researchers at all levels (investigator, study coordinator, study monitor, study staff) the fundamentals of a good clinical trial in the evaluation of a new drug or device, be it sponsored by an industry, federal or philanthropic organization. Whether the ultimate purpose is to create a clinical protocol, or to carry out or monitor a protocol, understanding the options and reasons for a clinical trial design impacts the daily conduct and success of the trial. Discussion starts with the evaluation process leading up to human volunteer trials, through elements in designing a trial, writing the scientific protocol, considering regulatory issues and human subjects protection, through elements in protocol development/implementation, sample size determination and analytic strategy.
PATH5070 Laboratory Animal Science 3 cr. Spring
This is an introductory course dealing with the care and use of animals in biomedical research. The course covers history of animal research, ethics and animal rights, Federal Regulations, the IACUC, and search for alternatives, animal models and research use. Also discussed are the husbandry, care and use of and common diseases and procedures in rats, mice and rabbits. The laboratory sessions provide the student with hands-on experience in handling the above species and an opportunity to practice the procedures as described. This 3-credit course is given as 11 one-hour didactic sessions each followed by a two-hour laboratory session. A midterm and a final exam are included
MSBS 5100 Current Molecular Techniques. 3 cr. Spring
The goal of this course is to provide graduate students with an understanding of the concepts and practice of contemporary molecular techniques. The emphasis of the course will be on exposure to and experience with methodologies. Therefore, a major aspect will be actual hands-on experience in basic research laboratories. There are three organizational modules and associated with each module are 7-10 techniques. Students will be divided into small groups (3-4) and will be assigned a technique. Senior graduate students, Post docs, or P.I.’s will offer direct training in laboratories currently using the technique, over the span of 1-2 days. Each small group will then make a presentation to the entire class. These presentations will include (1) a detailed protocol, (2) any data derived from the technique studied with experimental context and (3) a discussion of the strengths and weaknesses of the method. |
Certificate Program in Stem Cell Biology
A certificate in Stem Cell Biology (15 credits) is achieved by taking five required courses and one elective. Individuals should apply using the non-matriculates and certificate programs application form.
All students are required to take:
GSND N500A Fundamentals of Biomedical Sciences I. Biochemistry and Molecular Biology.
3 cr. Fall
This course is Part I of the evening fundamentals course that is given to Masters Students. This course covers basic biochemistry and molecular biology. The nature of the major macromolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.
GSND N500B Fundamentals of Biomedical Sciences II. Cellular Biology. 3 cr. Spring
This course is Part II of the evening fundamentals course that is given to Masters Students. In this course students are introduced to basic cellular structure and function. Topics include: an introduction to the techniques used for studying cell biology, biomembranes, cell compartments, exocytosis and endocytosis, the nucleus, cell cycle and apoptosis, cell signaling, cytoskeleton, extracellular matrix, angiogenesis, wound repair, cell surface specializations and junctions, and basic tissue biology of epithelia, connective tissue and nerve tissue. The lecture series provides an overview of important concepts in cell biology. Key experiments are described and some of the relevant topics of cell biology in the news are discussed.
MSBS 5130 Stem Cell Biology and Applications in Molecular Medicine. 3 cr. Fall
The goal is to develop the subject of stem cells from different tissues. The course will cover stem cell development from the blastocyst stage to the somatic stages. Bone marrow stem cells will be the prototype cells to discuss other stem cells. Different issues regarding regenerative medicine by stem cells will be discussed. The literature on bone marrow transplantation will be applied to repair medicine. Lectures will be didactic. Text books can be read but should be read with the knowledge that the literature on stem cell biology undergoes daily updates.
MSBS 520A Advanced Stem Cell Seminar. 2cr. Fall
This course is interactive. The goal is to provide students with insights on the translational implications for stem cell research. Recent publications will be discussed in class. Discussions will emphasize the implications for the research data in medicine.
MSBS N5134 Hematopoietic Stem Cell Biology and Dysfunction. 2cr. Spring
The purpose of this course is to provide students with an understanding of how dysfunctions in the hematopoietic stem cells lead to clinical abnormalities (diseases). In addition, students will learn how attempts are being made to solve the clinical problems and how these solutions were derived from an understanding of basic biology: biochemistry, cellular and molecular biology.
Hematology has been at the forefront of advances in non-bone marrow stem cells. The subject of hematology involves studies of bone marrow-resident stem cells and the influences of the microenvironment and the immune system on homeostasis of the bone marrow. An understanding of the aberrant stem cell mechanisms, which underlie hematological diseases, will provide paradigms for further study of other stem cells and their application in clinical medicine. This course will illustrate how our increasing knowledge of the biology of hematopoietic and, other bone marrow-derived stem cells can provide new insights into the clinical features of hematologic disease.
The following is an example of the stepwise method intended to discuss the pathophysiology of a hematological disorder:
- Lectures describing the basic science of the disease and the evolution of new drug targets.
- The outcome of clinical trials with the advent of drug resistance.
- Lectures on how the bedside outcome leads back to the bench.
Below are suggested elective course offerings. Other courses may be selected with approval.
CBMM 5020 Developmental Biology. 2 cr. Fall
CBMM 5350 Molecular Medicine of the Heart. 3cr. Fall
PATH N5211 Immunology. 3cr. Spring
Program Coordinator:
Pranela Rameshwar, Ph.D
Certificate Program in BioDefense
A certificate program in BioDefense (15 credits) is achieved by taking five required courses and one elective. Individuals should apply using the non-matriculates and certificate programs application form.
All certificate students are required to take:
GSND N500A Fundamentals of Biomedical Sciences I. Biochemistry and Molecular Biology. 3 cr Fall
This course is Part I of the evening fundamentals course that is given to Masters Students. This course covers basic biochemistry and molecular biology. The nature of the major macromolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.
GSND N500B Fundamentals of Biomedical Sciences II. Cellular Biology. 3 cr. Spring
This course is Part II of the evening fundamentals course that is given to Masters Students. In this course students are introduced to basic cellular structure and function. Topics include: an introduction to the techniques used for studying cell biology, biomembranes, cell compartments, exocytosis and endocytosis, the nucleus, cell cycle and apoptosis, cell signaling, cytoskeleton, extracellular matrix, angiogenesis, wound repair, cell surface specializations and junctions, and basic tissue biology of epithelia, connective tissue and nerve tissue. The lecture series provides an overview of important concepts in cell biology. Key experiments are described and some of the relevant topics of cell biology in the news are discussed.
MSBS N517Q Introduction to Select Agent Biology. 3 cr. Spring
This course is designed to give students a working knowledge of the various biological aspects of select agents and select agents research. The course topics include: select agents, bio-safety and regulations; host response to select agents; bacterial select agents and pathogenesis and virulence; viral select agents; toxins’ mechanisms of action. This course complements the other biodefense policy courses in the BioDefense Certificate Program.
MSBS N5010 Seminar in Homeland Security. 2 cr. Spring
This course provides students with an understanding of bioterrorism and homeland security issues through the discussion of current information related to bioterrorism and homeland security.
MSBS 5140 Biological Terrorism and Weapons of Mass Destruction. 3 cr. Fall
The goals of this course are to gain a knowledge of the history of agents of biological warfare, including political considerations, development, and use, and to relate this information to the potential for tactical/terrorist deployment; to gain a knowledge of the biology of agents of biological warfare and terrorism, including microbiology, genetics, immunology, identification, diagnosis, and disease; to gain an appreciation for the overall effects of biological weapons use, including detection and epidemiology, emergency response and management, and psychological impact; to understanding the difficulties in control and non-proliferation, including difficulties in fashioning a verification protocol to the current Biological Weapons Convention.
Below are suggested elective course offerings to complete the certificate.
Seminar in Biological Sciences 1 cr.
MICR 5620 21st Century Pathogens. 3 cr., Fall
This course provides an in-depth examination of selected viral, bacterial, fungal and parasitic infections agents. The course is structured with two parts; formal lecture and class discussion of primary literature. Topics covered include: tuberculosis, listeria, anthrax, DNA ciruses and retroviruses, HIV pathogenesis, Cryptococcus infections, antifungal drug mechanisms, trypanosomiasis and malaria.
MICRN 5233 Microbes and Infectious Disease, 3 cr., Spring
The objective of this course is to provide a general overview of bacterial, parasitic, fungal and viral infectious agents, as well as in-depth coverage of the molecular details of several select infectious agents. Topics discussed include basic virulence mechanisms, host interactions and defenses, mechanisms of pathogenesis and microbes in the news. The course is primarily designed for Masters level students, although all students may apply. In addition to lectures and written (short answer and essay) exams, students will be required to write a short report on a topic of their interest.
MSBS 5100 Current Molecular Techniques. 3 cr. Spring
The goal of this course is to provide graduate students with an understanding of the concepts and practice of contemporary molecular techniques. The emphasis of the course will be on exposure to and experience with methodologies. Therefore, a major aspect will be actual hands-on experience in basic research laboratories. There are three organizational modules and associated with each module are 7-10 techniques. Students will be divided into small groups (3-4) and will be assigned a technique. Senior graduate students, Post docs, or P.I.s will offer direct training in laboratories currently using the technique, over the span of 1-2 days. Each small group will then make a presentation to the entire class. These presentations will include (1) a detailed protocol, (2) any data derived from the technique studied with experimental context and (3) a discussion of the strengths and weaknesses
PATH N5211 Immunology. 3 cr. Spring
The goals of this course are to provide in-depth information on all aspects of modern immunology and bring the students up to date with the latest developments in the field of immunology. This course provides the basic concepts of both cellular and molecular immunology. Subjects covered include innate and acquired immune responses. The beginning of the course concentrates on the cells involved in the immune response, the mechanisms responsible for the generation of diversity in the immune response and aspects of the maturation of the immune response. Topics covered extend to cellular interactions, complement system, cytokine networks, antigen processing, immune completes, and signal transduction. The last third of the course concentrates on alterations in immunity that occur following infection, the interactions between neural and immune systems, autoimmunity, hypersensitivity, cancer, transplantation, and immunodeficiency. This course is taught by faculty whose course interests and expertise involve immunology. Evaluation will be based on a mid term, a final, and a student paper evaluation of literature reports.
PATH 5220 Fundamentals of Immunology. 2 cr.
Introductory level course in immunology, covering the basic concepts of the cells and humoral products of the immune system, the genetics of immunoglobulin production, and antigen - antibody reactions. Using an approach that correlates these basic concepts with clinical manifestations of disease, the immunopathologic mechanisms of hypersensitivity, autoimmunity, transplantation, tumor immunology and immunodeficiency are presented.
For an application or further information contact:
Stephen Garrett, Ph.D.
Assistant Professor
Department of Microbiology and Molecular Genetics
UMDNJ-New Jersey Medical School
garretsts@umdnj.edu
Tel: 973-972-4483 ext. 20698
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