Marshall Islands in Health Emergency over TB Outbreak
Agence France Presse, January 30, 2010
CDC and the World Health Organization are assisting the Marshall Islands in responding to an outbreak of drug-resistant TB - a situation being described as a “public health emergency” in the Western Pacific nation. In less than two months, the number of drug-resistant TB cases has climbed from six to 10. Health officials are tracking up to 500 contacts of these patients. “It is still too early to tell how many will need to be isolated for drug-resistant TB,” said Majuro Hospital Chief of Staff Dr. Marie Lanwi-Paul. Read more [+/-]
“We are in the process of doubling the bed capacity” in the TB isolation unit, she said. Government officials said Saturday they are considering invoking special quarantine powers to help deal with the outbreak. Health Minister Amenta Matthew said she is drafting legislation to give the director of health power to quarantine persons who do not voluntarily comply with TB prevention requirements. “Currently, there are patients who continuously move around the community with TB disease, posing the threat of exposing others to the disease,” said Matthew. The archipelago of some 55,000 people would be better served by doing away with the lengthy court process now required and giving the public health director authority to place patients in isolation, she said. In January, a patient was brought to court for failing to take treatment and remain in isolation. The judge, lawyers, witnesses, and defendant were required to wear masks to prevent the spread of TB during the hearing, but the session ended inconclusively, and the patient returned to the community.
African Trial Finds Vaccine Effective against HIV-Associated TB (Tanzania)
Pharma Times, www.pharmatimes.com February 1, 2010
Researchers from Dartmouth Medical School (DMS) announced favorable results of a seven-year clinical trial of a new vaccine against TB. The DarDar Health Study showed that the vaccine reduced the rate of TB by 39 percent among 2,000 HIV-infected patients in Tanzania. The researchers used a strategy for immunization with Mycobacterium vaccae (MV) vaccine, before patients began antiretroviral drug treatment. MV is an inactivated whole-cell mycobacterial vaccine. Read more [+/-]
The randomized, placebo-controlled trial was conducted with the involvement of Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam, Tanzania, and was supported by a grant from the US National Institute of Allergy and Infectious Diseases. According to Dr. Ford von Reyn, Director of the DarDar International Programs for the Section on Infectious Disease and International Health at DMS, the next step would be to improve manufacturing methods so that larger quantities of the vaccine could be produced for further studies and clinical use. Development of the vaccine will be done by the Aeras Global TB Vaccine Foundation in Rockville, MD, United States, in conjunction with Immodulon Therapeutics of the United Kingdom.